EMD-386088

EMD-386088

Systematic (IUPAC) name
5-chloro-2-methyl-3-(1,2,3,6-tetrahydro-4-pyridinyl)-1H-indole
Identifiers
CAS Number	54635-62-0 Y
ATC code	none
PubChem	CID: 10131112
Chemical data
Formula	C14H14ClN2
Molecular mass	245.727 g/mol
SMILES Clc2cc1c(cc2)nc(C)c1C=3CCNCC=3
(verify)

EMD-386088 is an indole derivative which is used in scientific research. It acts as a potent 5-HT₆ receptor partial agonist, with a K_i of 1 nM, a significantly higher affinity than older 5-HT₆ agonists such as EMDT, although it possesses moderate affinity for the 5-HT₃ receptor as well. Subsequent research has determined that EMD-386088 is also a dopamine reuptake inhibitor and that this action is involved in the antidepressant-like effects of the drug in rodents.

See also

• EMDT
• ST-1936