Fedotozine

Fedotozine
Systematic (IUPAC) name
	(2R)-N,N-dimethyl-2-phenyl-1-[(3,4,5-trimethoxybenzyl)oxy]-2-butanamine
Clinical data
Legal status	Non-regulated;
Routes of; administration	Oral
Identifiers
CAS Number	123618-00-8; 133267-27-3 (tartrate)
ATC code	None
PubChem	CID: 6918160
ChemSpider	5293373
ChEMBL	CHEMBL2106275
Chemical data
Formula	C22H31NO4
Molecular mass	373.486 g/mol
	SMILES O(c1cc(cc(OC)c1OC)COC[C@@](c2ccccc2)(N(C)C)CC)C ;
	InChI InChI=1S/C22H31NO4/c1-7-22(23(2)3,18-11-9-8-10-12-18)16-27-15-17-13-19(24-4)21(26-6)20(14-17)25-5/h8-14H,7,15-16H2,1-6H3/t22-/m0/s1 ; Key:MVKIWCDXKCUDEH-QFIPXVFZSA-N ;

Fedotozine (INN; Jo-1196) is an opioid drug of the arylacetamide series which acts as a peripherally-specific, selective κ₁-opioid receptor agonist with preference for the κ_1A subtype.^[1] It was under investigation for the treatment of gastrointestinal conditions like irritable bowel syndrome and functional dyspepsia and made it to phase III clinical trials,^[1]^[2]^[3] but ultimately development was discontinued and it was never marketed.

References