Mecloqualone

Mecloqualone

Systematic (IUPAC) name
3-(2-chlorophenyl)-2-methylquinazolin-4(3H)-one
Clinical data
Legal status	CA: Schedule III DE: Anlage I (Controlled) US: Schedule I
Identifiers
CAS Number	340-57-8 N
ATC code	none
PubChem	CID: 9567
ChemSpider	9192 Y
UNII	09XU4VDV7E Y
KEGG	D04877 Y
ChEMBL	CHEMBL279960 Y
Chemical data
Formula	C15H11ClN2O
Molecular mass	270.714
SMILES Clc3ccccc3N/1C(=O)c2c(\N=C\1C)cccc2
InChI InChI=1S/C15H11ClN2O/c1-10-17-13-8-4-2-6-11(13)15(19)18(10)14-9-5-3-7-12(14)16/h2-9H,1H3 Y Key:SFITWQDBYUMAPS-UHFFFAOYSA-N Y
NY (what is this?)  (verify)

Mecloqualone (Nubarene, Casfen) is a quinazolinone-class GABAergic and is an analogue of methaqualone that was first made in 1960 and marketed mainly in France and some other European countries. It has sedative, hypnotic, and anxiolytic properties caused by its agonist activity at the β subtype of the GABA_a receptor, and was used for the treatment of insomnia. Mecloqualone is faster-acting but shorter-lasting than methaqualone and so was used only as a sleeping pill, in contrast to methaqualone, which was used as a general-purpose anxiolytic as well. Mecloqualone was never as widely used as methaqualone and is no longer prescribed because of concerns about its potential for abuse and overdose. In the United States it is a Schedule I non-narcotic (depressant) controlled substance with an ACSCN of 2572 and zero annual aggregate manufacturing quota.

See also

• Methaqualone
• Afloqualone
• Etaqualone
• Methylmethaqualone
• Mebroqualone
• Cloroqualone
• Diproqualone
• Gamma-Aminobutyric acid