ZK-93423

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ZK-93423
ZK-93423 structure.png
Systematic (IUPAC) name
ethyl 4-(methoxymethyl)-6-(phenylmethoxy) -9H-pyrido[5,4-b]indole-3-carboxylate
Clinical data
Legal status
  • legal
Identifiers
CAS Number 83910-44-5 YesY
ATC code none
PubChem CID: 121926
IUPHAR/BPS 4346
ChemSpider 108771 N
Chemical data
Formula C23H22N2O4
Molecular mass 390.431 g/mol
  • c3ccccc3COc(cc4)cc2c4nc(cnc1C(=O)OCC)c2c1COC
  • InChI=1S/C23H22N2O4/c1-3-28-23(26)22-18(14-27-2)21-17-11-16(29-13-15-7-5-4-6-8-15)9-10-19(17)25-20(21)12-24-22/h4-12,25H,3,13-14H2,1-2H3 N
  • Key:ALBKMJDFBZVHAK-UHFFFAOYSA-N N
 NYesY (what is this?)  (verify)

ZK-93423 is an anxiolytic drug from the β-Carboline family, closely related to abecarnil.[1] It is a nonbenzodiazepine GABAA agonist which is not subtype selective and stimulates α1, α2, α3, and α5-subunit containing GABAA receptors equally.[2] It has anticonvulsant, muscle relaxant and appetite stimulating properties comparable to benzodiazepine drugs.[3][4][5][6] ZK-93423 has also been used as a base to develop new and improved beta-carboline derivatives and help map the binding site of the GABAA receptor.[7][8][9][10][11][12]

See also

References

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