Medetomidin

Medetomidin
(IUPAC) ime
	(RS)-4-[1-(2,3-dimetilfenil)etil]-3H-imidazol
Klinički podaci
AHFS/Drugs.com	Monografija
Identifikatori
CAS broj	86347-14-0
ATCvet kod	QN05CM91
PubChem	68602
DrugBank	DB00633
ChemSpider	61868
UNII	MR15E85MQM
KEGG	D08165
ChEBI	CHEBI:48552
ChEMBL	CHEMBL77921
Hemijski podaci
Formula	C13H16N2
Mol. masa	200,279 g/mol
SMILES	eMolekuli & PubHem
InChI
	InChI=1S/C13H16N2/c1-9-5-4-6-12(10(9)2)11(3)13-7-14-8-15-13/h4-8,11H,1-3H3,(H,14,15) ; Key: CUHVIMMYOGQXCV-UHFFFAOYSA-N
Farmakoinformacioni podaci
Trudnoća	?
Pravni status	Samo za veterinarsku upotrebu

Medetomidin je sintetički lek koji se koristi kao hirurški anestetik i analgetik. On se često koristi u obliku hidrohloridne soli medetomidin hidrohlorida. On je kristalna bela materija. Medetomidin deluje kao alfa-dva adrenergički agonist^[6] koji se može dozirati kao intravenozni rastvor u sterilnoj vodi. On je odobren za pse Sjedinjenim Državama. Disribuiraju ga kompanije Pfizer i Novartis. Drugi alfa-dva agonisti se isto tako koriste u veterini, npr. ksilazin i detomidin, ali se oni ređe koriste kao anestetici za male životinje.

Reference

↑ Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519. edit
↑ Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.
↑ Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). „Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining”. J Cheminform 2 (1): 3. DOI:10.1186/1758-2946-2-3. PMID 20331846. edit
↑ Joanne Wixon, Douglas Kell (2000). „Website Review: The Kyoto Encyclopedia of Genes and Genomes — KEGG”. Yeast 17 (1): 48–55. DOI:10.1002/(SICI)1097-0061(200004)17:1<48::AID-YEA2>3.0.CO;2-H.
↑ Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP. (2012). „ChEMBL: a large-scale bioactivity database for drug discovery”. Nucleic Acids Res 40 (Database issue): D1100-7. DOI:10.1093/nar/gkr777. PMID 21948594. edit
↑ Sinclair MD (November 2003). „A review of the physiological effects of alpha2-agonists related to the clinical use of medetomidine in small animal practice”. Can. Vet. J. 44 (11): 885–97. PMC 385445. PMID 14664351.

Literatura

Harari, Joseph (1996). Small Animal Surgery. Williams and Wilkins. ISBN 978-0-683-03910-8.
Lind, U.; Alm Rosenblad, M.; Hasselberg Frank, L.; Falkbring, S.; Brive, L.; Laurila, J. M.; Pohjanoksa, K.; Vuorenpaa, A. i dr.. (2010). „Octopamine Receptors from the Barnacle Balanus improvisus Are Activated by the 2-Adrenoceptor Agonist Medetomidine”. Molecular Pharmacology 78 (2): 237–248. DOI:10.1124/mol.110.063594. PMID 20488921.
Dahlström, M.; Mårtensson, L. G.; Jonsson, P. R.; Arnebrant, T.; Elwing, H. (2000). „Surface active adrenoceptor compounds prevent the settlement of cyprid larvae ofBalanus improvisus”. Biofouling 16 (2–4): 191. DOI:10.1080/08927010009378444.

Spoljašnje veze

	Portal Medicina
	Portal Hemija

[1] Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519. edit

[2] Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.

[3] Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). „Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining”. J Cheminform 2 (1): 3. DOI:10.1186/1758-2946-2-3. PMID 20331846. edit

[4] Joanne Wixon, Douglas Kell (2000). „Website Review: The Kyoto Encyclopedia of Genes and Genomes — KEGG”. Yeast 17 (1): 48–55. DOI:10.1002/(SICI)1097-0061(200004)17:1<48::AID-YEA2>3.0.CO;2-H.

[5] Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP. (2012). „ChEMBL: a large-scale bioactivity database for drug discovery”. Nucleic Acids Res 40 (Database issue): D1100-7. DOI:10.1093/nar/gkr777. PMID 21948594. edit

[pmid14664351-6] Sinclair MD (November 2003). „A review of the physiological effects of alpha2-agonists related to the clinical use of medetomidine in small animal practice”. Can. Vet. J. 44 (11): 885–97. PMC 385445. PMID 14664351.

[1]

[2]

[3]

[4]

[5]

[6]