SB-204,741

SB-204,741
(IUPAC) ime
	N-(1-Metil-1H-indol-5-il)-N'-(3-metilizotiazol-5-il)ureja
Klinički podaci
Identifikatori
CAS broj	152239-46-8
ATC kod	nije dodeljen
PubChem	3277600
Hemijski podaci
Formula	C14H14N4OS
Mol. masa	286,352 g/mol
SMILES	eMolekuli & PubHem
InChI
	InChI=1S/C14H14N4OS/c1-9-7-13(20-17-9)16-14(19)15-11-3-4-12-10(8-11)5-6-18(12)2/h3-8H,1-2H3,(H2,15,16,19) ; Key: USFUFHFQWXDVMH-UHFFFAOYSA-N
Sinonimi	SB-204,741
Farmakoinformacioni podaci
Trudnoća	?
Pravni status

SB-204,741 je lek koji deluje kao potentan i selektivan antagonist na serotoninskom 5-HT_2B receptoru, sa oko 135x selektivnošću u odnosu na blisko srodni 5-HT_2C receptor, i još većom u odnosu na 5-HT_2A receptor.^[3] On se koristi u naučnim istraživanjima za ispitivanje funkcije 5-HT_2B receptora.^[4]^[5]^[6]^[7]

Reference

↑ Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519. edit
↑ Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.
↑ Forbes, IT; Jones, GE; Murphy, OE; Holland, V; Baxter, GS (1995). „N-(1-methyl-5-indolyl)-N'-(3-methyl-5-isothiazolyl)urea: a novel, high-affinity 5-HT2B receptor antagonist”. Journal of Medical Chemistry 38 (6): 855–7. DOI:10.1021/jm00006a001. PMID 7699699.
↑ Glusa, E; Pertz, HH (2000). „Further evidence that 5-HT-induced relaxation of pig pulmonary artery is mediated by endothelial 5-HT2B receptors”. British Journal of Pharmacology 130 (3): 692–8. DOI:10.1038/sj.bjp.0703341. PMC 1572101. PMID 10821800.
↑ Holohean, AM; Hackman, JC (2004). „Mechanisms intrinsic to 5-HT2B receptor-induced potentiation of NMDA receptor responses in frog motoneurones”. British Journal of Pharmacology 143 (3): 351–60. DOI:10.1038/sj.bjp.0705935. PMC 1575347. PMID 15339859.
↑ Papageorgiou, A; Denef, C (2007). „Stimulation of growth hormone release by 5-hydroxytryptamine (5-HT) in cultured rat anterior pituitary cell aggregates: evidence for mediation by 5-HT2B, 5-HT7, 5-HT1B, and ketanserin-sensitive receptors”. Endocrinology 148 (9): 4509–22. DOI:10.1210/en.2007-0034. PMID 17584957.
↑ Wouters, MM; Gibbons, SJ; Roeder, JL; Distad, M; Ou, Y; Strege, PR; Szurszewski, JH; Farrugia, G (2007). „Exogenous serotonin regulates proliferation of interstitial cells of Cajal in mouse jejunum through 5-HT2B receptors”. Gastroenterology 133 (3): 897–906. DOI:10.1053/j.gastro.2007.06.017. PMID 17854596.

Spoljašnje veze

	Portal Medicina
	Portal Hemija

[1] Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519. edit

[2] Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.

[3] Forbes, IT; Jones, GE; Murphy, OE; Holland, V; Baxter, GS (1995). „N-(1-methyl-5-indolyl)-N'-(3-methyl-5-isothiazolyl)urea: a novel, high-affinity 5-HT2B receptor antagonist”. Journal of Medical Chemistry 38 (6): 855–7. DOI:10.1021/jm00006a001. PMID 7699699.

[4] Glusa, E; Pertz, HH (2000). „Further evidence that 5-HT-induced relaxation of pig pulmonary artery is mediated by endothelial 5-HT2B receptors”. British Journal of Pharmacology 130 (3): 692–8. DOI:10.1038/sj.bjp.0703341. PMC 1572101. PMID 10821800.

[5] Holohean, AM; Hackman, JC (2004). „Mechanisms intrinsic to 5-HT2B receptor-induced potentiation of NMDA receptor responses in frog motoneurones”. British Journal of Pharmacology 143 (3): 351–60. DOI:10.1038/sj.bjp.0705935. PMC 1575347. PMID 15339859.

[6] Papageorgiou, A; Denef, C (2007). „Stimulation of growth hormone release by 5-hydroxytryptamine (5-HT) in cultured rat anterior pituitary cell aggregates: evidence for mediation by 5-HT2B, 5-HT7, 5-HT1B, and ketanserin-sensitive receptors”. Endocrinology 148 (9): 4509–22. DOI:10.1210/en.2007-0034. PMID 17584957.

[7] Wouters, MM; Gibbons, SJ; Roeder, JL; Distad, M; Ou, Y; Strege, PR; Szurszewski, JH; Farrugia, G (2007). „Exogenous serotonin regulates proliferation of interstitial cells of Cajal in mouse jejunum through 5-HT2B receptors”. Gastroenterology 133 (3): 897–906. DOI:10.1053/j.gastro.2007.06.017. PMID 17854596.

[1]

[2]

[3]

[4]

[5]

[6]

[7]