Enoksacin

Enoksacin
IUPAC ime
	1-etil-6-fluoro-4-okso-7-(piperazin-1-il)-1,4-dihidro-1,8-naftiridin-3-karboksilna kiselina
Klinički podaci
Drugs.com	Monografija
MedlinePlus	a601013
Način primene	Oralno
Identifikatori
CAS broj	74011-58-8
ATC kod	J01MA04 (WHO)
PubChem	CID 3229
DrugBank	DB00467
ChemSpider	3116
UNII	325OGW249P
KEGG	D00310
ChEBI	CHEBI:157175
ChEMBL	CHEMBL826
Hemijski podaci
Formula	C15H17FN4O3
Molarna masa	320,319 g/mol
	SMILES Fc1c(nc2c(c1)C(=O)C(\C(=O)O)=C/N2CC)N3CCNCC3; ;
	InChI InChI=1S/C15H17FN4O3/c1-2-19-8-10(15(22)23)12(21)9-7-11(16)14(18-13(9)19)20-5-3-17-4-6-20/h7-8,17H,2-6H2,1H3,(H,22,23) ; Key:IDYZIJYBMGIQMJ-UHFFFAOYSA-N ;

Enoksacin (Almitil, Bactidan, Bactidron, Comprecin, Enoksetin, Enoxen, Enroxil, Enoxin, Enoxor, Flumark, Penetrex, Gyramid, Vinone) je oralni fluorohinolonski antibakterijski agens širokog spektra koji se koristi u tretmanu infekcija urinarnog trakta i gonoreja. Insomnija je česta nuspojava pri upotrebi ovog leka.^[1]^[2]

Nedavno je pokazano da ova supstanca može da inhibira kancer.^[3]

Reference

^ Rafalsky, V.; Andreeva, I.; Rjabkova, E.; Rafalsky, Vladimir V (2006). Rafalsky, Vladimir V, ур. „Quinolones for uncomplicated acute cystitis in women”. Cochrane Database Syst Rev. 3: CD003597. PMID 16856014. doi:10.1002/14651858.CD003597.pub2.
^ Mogabgab, WJ. (1991). „Recent developments in the treatment of sexually transmitted diseases”. Am J Med. 91 (6A): 140S—144S. PMID 1767802. doi:10.1016/0002-9343(91)90327-T.
^ Sonia Melo; Alberto Villanueva; Catia Moutinho; Veronica Davalos; Riccardo Spizzo; Cristina Ivan; Simona Rossi; Fernando Setien; Oriol Casanovas; Laia Simo-Riudalbas; Javier Carmona; Jordi Carrere; August Vidal; Alvaro Aytes; Sara Puertas; Santiago Ropero; Raghu Kalluri; Carlo M. Croce; George A. Calin; Manel Estellera (2011). „Small molecule enoxacin is a cancer-specific growth inhibitor that acts by enhancing TAR RNA-binding protein 2-mediated microRNA processing”. PNAS. doi:10.1073/pnas.1014720108.

Literatura

Patel, SS; Spencer, CM (1996). „Enoxacin: a reappraisal of its clinical efficacy in the treatment of genitourinary tract infections”. Drugs. 51 (1): 137—60. PMID 8741236. .

Spoljašnje veze

Medline entry

Molimo Vas, obratite pažnju na važno upozorenje
u vezi sa temama iz oblasti medicine (zdravlja).

[1] Rafalsky, V.; Andreeva, I.; Rjabkova, E.; Rafalsky, Vladimir V (2006). Rafalsky, Vladimir V, ур. „Quinolones for uncomplicated acute cystitis in women”. Cochrane Database Syst Rev. 3: CD003597. PMID 16856014. doi:10.1002/14651858.CD003597.pub2.

[2] Mogabgab, WJ. (1991). „Recent developments in the treatment of sexually transmitted diseases”. Am J Med. 91 (6A): 140S—144S. PMID 1767802. doi:10.1016/0002-9343(91)90327-T.

[3] Sonia Melo; Alberto Villanueva; Catia Moutinho; Veronica Davalos; Riccardo Spizzo; Cristina Ivan; Simona Rossi; Fernando Setien; Oriol Casanovas; Laia Simo-Riudalbas; Javier Carmona; Jordi Carrere; August Vidal; Alvaro Aytes; Sara Puertas; Santiago Ropero; Raghu Kalluri; Carlo M. Croce; George A. Calin; Manel Estellera (2011). „Small molecule enoxacin is a cancer-specific growth inhibitor that acts by enhancing TAR RNA-binding protein 2-mediated microRNA processing”. PNAS. doi:10.1073/pnas.1014720108.

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