LY-379,268

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LY-379,268
LY3792682DACS.svg
Systematic (IUPAC) name
(1S,2R,5R,6R)-2-amino-4-oxabicyclo[3.1.0]hexane-2,6-dicarboxylic acid
Identifiers
CAS Number 191471-52-0 YesY
PubChem CID: 10197984
ChemSpider 8373484 N
Chemical data
Formula C7H9NO5
Molecular mass 187.150 g/mol
  • C1[C@]([C@@H]2[C@H]([C@@H]2O1)C(=O)O)(C(=O)O)N
  • InChI=1S/C7H9NO5/c8-7(6(11)12)1-13-4-2(3(4)7)5(9)10/h2-4H,1,8H2,(H,9,10)(H,11,12)/t2-,3-,4+,7+/m1/s1 N
  • Key:YASVRZWVUGJELU-MDASVERJSA-N N
 NYesY (what is this?)  (verify)

LY-379,268 is a drug that is used in neuroscience research, which acts as a potent and selective agonist for the group II metabotropic glutamate receptors (mGluR2/3).

It is derived from the older mGluR group II agonist eglumegad,[1] and led on to the development of the more potent compound LY-404,039,[2] but is still widely used in research itself. LY-379,268 has sedative, neuroprotective, anti-addictive and anticonvulsant effects in animals,[3][4][5] and blocks the effects of PCP and DOI,[6][7][8][9] which has led to research into LY-379,268 and similar compounds as antipsychotic drugs for the treatment of schizophrenia.[10][11]

There are inconsistent findings about an additional activity as a dopamine D2 receptor partial agonist.[12][13]

See also

References

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