ML-154

ML-154
Systematic (IUPAC) name
	3-(diphenylphosphinothioyl)-2-methyl-1-[(2E)-3-phenyl-2-propen-1-yl]imidazo[1,2-a]pyridinium bromide
Identifiers
CAS Number	1345964-89-7
ATC code	none
PubChem	CID: 46930969
ChemSpider	26360842
Chemical data
Formula	C29H26BrN2PS
Molecular mass	545.472 g/mol
	SMILES [Br-].C1(=CC=CC=C1)[P](=S)(C2=C([N+](=C3C=CC=C[N]23)C\C=C\C4=CC=CC=C4)C)C5=CC=CC=C5 ;
	InChI InChI=1S/C29H26N2PS.BrH/c1-24-29(32(33,26-17-7-3-8-18-26)27-19-9-4-10-20-27)31-22-12-11-21-28(31)30(24)23-13-16-25-14-5-2-6-15-25;/h2-22H,23H2,1H3;1H/q+1;/p-1/b16-13+; ; Key:CJAQCMBWGUOBIX-ZUQRMPMESA-M ;

ML-154 (NCGC-84) is a drug which acts as a selective, non-peptide antagonist at the neuropeptide S receptor NPSR.^[1] In animal studies it decreases self-administration of alcohol in addicted rats, and lowers motivation for alcohol rewards, suggesting a potential application for NPS antagonists in the treatment of alcoholism.^[2]

References

↑ Patnaik S, Marugan JJ, Liu K, Zheng W, Southall N, Dehdashti SJ, Thorsell A, Heilig M, Bell L, Zook M, Eskay B, Brimacombe KR, Austin CP. Structure-activity relationship of imidazopyridinium analogues as antagonists of neuropeptide S receptor. J Med Chem. 2013 Nov 27;56(22):9045-56. doi: 10.1021/jm400904m PMID 24171469
↑ Thorsell A, Tapocik JD, Liu K, Zook M, Bell L, Flanigan M, Patnaik S, Marugan J, Damadzic R, Dehdashti SJ, Schwandt ML, Southall N, Austin CP, Eskay R, Ciccocioppo R, Zheng W, Heilig M. A novel brain penetrant NPS receptor antagonist, NCGC00185684, blocks alcohol-induced ERK-phosphorylation in the central amygdala and decreases operant alcohol self-administration in rats. J Neurosci. 2013 Jun 12;33(24):10132-42. doi: 10.1523/JNEUROSCI.4742-12.2013 PMID 23761908

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[1] Patnaik S, Marugan JJ, Liu K, Zheng W, Southall N, Dehdashti SJ, Thorsell A, Heilig M, Bell L, Zook M, Eskay B, Brimacombe KR, Austin CP. Structure-activity relationship of imidazopyridinium analogues as antagonists of neuropeptide S receptor. J Med Chem. 2013 Nov 27;56(22):9045-56. doi: 10.1021/jm400904m PMID 24171469

[2] Thorsell A, Tapocik JD, Liu K, Zook M, Bell L, Flanigan M, Patnaik S, Marugan J, Damadzic R, Dehdashti SJ, Schwandt ML, Southall N, Austin CP, Eskay R, Ciccocioppo R, Zheng W, Heilig M. A novel brain penetrant NPS receptor antagonist, NCGC00185684, blocks alcohol-induced ERK-phosphorylation in the central amygdala and decreases operant alcohol self-administration in rats. J Neurosci. 2013 Jun 12;33(24):10132-42. doi: 10.1523/JNEUROSCI.4742-12.2013 PMID 23761908

[1]

[2]

ML-154

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