SIRPB1
Lua error in Module:Infobox_gene at line 33: attempt to index field 'wikibase' (a nil value). Signal-regulatory protein beta-1 is a protein that in humans is encoded by the SIRPB1 gene.[1][2][3] SIRPB1 has also recently been designated CD172B (cluster of differentiation 172B).
The protein encoded by this gene is a member of the signal-regulatory-protein (SIRP) family, and also belongs to the immunoglobulin superfamily. SIRP family members are receptor-type transmembrane glycoproteins known to be involved in the negative regulation of receptor tyrosine kinase-coupled signaling processes. This protein was found to interact with TYROBP/DAP12, a protein bearing immunoreceptor tyrosine-based activation motifs. This protein was also reported to participate in the recruitment of tyrosine kinase SYK. Alternatively spliced transcript variants have been found for this gene.[3]
Interactions
SIRPB1 has been shown to interact with TYROBP.[4][5]
References
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Further reading
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External links
- SIRPB1 human gene location in the UCSC Genome Browser.
- SIRPB1 human gene details in the UCSC Genome Browser.
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This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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