Talipexole

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Talipexole
Talipexole.svg
Talipexole-3D-balls.png
Systematic (IUPAC) name
6-allyl-5,6,7,8-tetrahydro-4H-[1,3]thiazolo[4,5-d]azepin-2-amine
Clinical data
Trade names Domin
AHFS/Drugs.com International Drug Names
Legal status
  • ℞ (Prescription only)
Routes of
administration		 Oral
Identifiers
CAS Number 36085-73-1 N
ATC code none
PubChem CID: 5374
IUPHAR/BPS 5442
ChemSpider 5181 N
UNII 7AM2J46Z1Y N
ChEMBL CHEMBL1289023 N
Synonyms Alefexole
Chemical data
Formula C10H15N3S
Molecular mass 209.31 g/mol
  • n1c2c(sc1N)CCN(CC2)C\C=C
  • InChI=1S/C10H15N3S/c1-2-5-13-6-3-8-9(4-7-13)14-10(11)12-8/h2H,1,3-7H2,(H2,11,12) N
  • Key:DHSSDEDRBUKTQY-UHFFFAOYSA-N N
 NYesY (what is this?)  (verify)

Talipexole (B-HT920, Domnin) is a dopamine agonist that is marketed as a treatment for Parkinson's Disease in Japan by Boehringer Ingelheim; it was introduced in 1996.[1] As of December 2014 it was not approved for marketing in the US nor in Europe.[2]

Talipexole is a D2 dopamine receptor agonist and interacts both pre- and post-synaptic receptors. It also is an α2-adrenergic agonist.[3]

The main side effects are drowsiness, dizziness, hallucinations and minor gastrointestinal complaints.[3] In 2008 the Japanese Ministry of Health, Labour, and Welfare mandated that Boehringer add a warning to the label concerning the risk of sudden onset of sleep.[4]:15

References

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Stub icon

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  1. ↑ PharmaLetter 22 July 1996 First Launch In Japan For Talipexole
  2. ↑ EvaluatePharma Database. Page accessed 9 December 2014
  3. ↑ 3.0 3.1 Benkert O, et al. Dopamine agonists in schizophrenia: a review. Eur Neuropsychopharmacol. 1995;5 Suppl:43-53. PMID 8775758
  4. ↑ Japanese Ministry of Health, Labour and Welfare March 2008 Pharmaceuticals and Medical Devices Safety Information No. 245
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