| l l l l l | | | | | | | l l l l l l l l | l | l | l l l l l I I I I I l l l l l I l l l l I l l I I l l l l l I l | l | | I l l | | | | l I l l l

USOO5676977A
United States Patent [ 1 91 [ 1 1 ] Patent N u m b er : 5, 676, 977
Antel m an [ 4 5] Date o f Patent: Oc t. 1 4 , 1 997
[ 54 ] METHOD OFCURI N GAI DS WI TH 5, 3 3 6, 4 99 8 / 1 994 Antel m an . . . . . . . . . . . . . . . . . . . . 4 2 4 / 4 0 5
TETRASI LVERTETROXm EMOLECULAR 5, 571 , 52 0 1 1 / 1 996 Antel m an . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 4 2 4 / 61 8
CRYSTALDEVI CES OTHERPUBLI CATI ON S
I s The AI DS Vir u s A Sc ienc e Fic tio n? b y Peter H. Du es
b er g and Br yan J . El l iso n. Po l ic y Rev iew , Su m m er 1 990 , p p .
4 0 - 51 .
Pr im ar y Ex am iner Am y Hu l ina
Atto r ney, Ag ent, o r Fir m - Sa1 ter &Mic hael so n
[ 57] ABSTRACT
[ 75] I nv ento r : Mar v in S. Antel m an, Reho v o t, I sr ael
[ 73 ] Assig nee: Antel m an Tec hno l o g ies Ltd. ,
Pr o v idenc e, R1 .
[ 2 1 ] Ap p l . N o . : 658 , 955
[ 2 2 ] Fil ed: May 3 1 , 1 996
The diam ag netic sem ic o ndu c ting m o l ec u l ar c r ystal tetr asil
Rel ated US. Ap p l ic atio n Data
v er tetr o x ide ( Ag 4 O4 ) is u til iz ed f o r destr o ying the AI DS
v ir u s, destr o ying AI DS syner g istic p atho g ens and im m u nity
[ 63 ] Cl p nt nu ? o n- in- p ar t o f Ser . N o . 3 1 0 , 8 59, Sep . 2 2 , 1 994 , su p p r essing m o ieties ( I SM) in hu m ans,
a an o n .
6 A sing l e intr av eno u s inj ec tio n o f the dev ic es is al l that is
I nt. Cl . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . r eq u ir ed f o r c ? ic ac y at l ev c l s o f ab o u t 4 0 PPMo f hu m an
_ b l o o d. The dev ic e m o l ec u l ar c r ystal c o ntains tw o m o no and
Fl el d o f Sear c h . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . tw o tr iv al ent sil v er io ns Cap ab l e o f ? r ing el ? c tr o ns c ap ab l e
. o f el ec tr o c u n' ng the AI DS v ir u s, atho ens and I SM. When
[ 5 6] Ref em nc es Cl ted adm inister ed into the b l o o dstr ear ? , theg dev ic e el ec tr o ns w il l
U. S. PATEN TDOCUI VI EN TS b e tr ig g er ed b y p atho g ens, a p r o l if er ating v ir u s and I SM,
and w hen ? r ed w il l sim u l taneo u sl y tr ig g er a r edo x c hel atio n
m ec hanism r esu l ting in div al ent sil v er m o ieties w hic h c he
4 952 4 1 1 8 1 1 990 l ate and b ind ac tiv e sites o f the entities destr o ying them . The
5: 0 73 : 3 8 2 1 2 / 1 991 dev ic es ar e c o m p l etel y no n- to x ic . Ho w ev er . they p u t str ess
5, 0 73 7% 1 / 1 992 o n the l iv er c au sing hep ato m eg al y, b u t ther e is no l o ss o f
5, 0 3 9, 2 75 2 / 1 992 l iv er f u nc tio n.
5, 2 1 1 , 8 55 5/ 1 993 - . . 5, 2 2 3 , 1 4 9 6/ 1 993 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 4 2 4 / 61 8 3 Cl aim s, N 0 Dr aw ing s
5, 676, 977
1
METHOD OFCURI N GAI DS WI TH
TETRASI LVERTETROXI DEMOLECULAR
CRYSTALDEVI CES
This ap p l ic atio n is a c o ntinu atio n- in- p ar t o f p atent ap p l i
c atio n Ser . N o . 0 8 / 3 1 0 , 8 59 ? l ed Sep . 2 2 , 1 994 , no w ab an
do ned.
BACKGROUN D OFTHEI N VEN TI ON
The p r esent inv entio n r el ates to the em p l o ym ent o f
m o l ec u l ar c r ystal s as anti- AI DS dev ic es, b u t m o r e p ar tic u
l ar l y to the m o l ec u l ar c r ystal sem ic o ndu c to r tetr asil v er
tetr o x ide Ag 4 O4 w hic h has tw o m o no v al ent and tw o tr iv a
l ent sil v er io ns p er m o l ec u l e, and w hic h thr o u g h this str u c
tu r al c o n? g u r atio n enab l es inter m o l ec u l ar el ec tr o n tr ansf er
c ap ab l e o f k il l ing v ir u ses and b inding them to the r esu l ting
sil v er entity so that a sing l e intr av eno u s inj ec tio n w il l
c o m p l etel y o b l iter ate ac q u ir ed im m u ne de? c ienc y syndr o m e
( AI DS) in hu m ans. Fu r ther m o r e, said dev ic es ar e c ap ab l e o f
k il l ing p atho g ens and p u r g ing the b l o o dstr eam o f im m u ne
su p p r essing m o ieties ( I SM) w hether o r no t c r eated b y the
AI DS v ir u s ( HI V) ; so as to r esto r e the im m u ne system
The p r esent inv entio n is b ased o n c o nc ep ts p r ev io u sl y
el u c idated in ap p l ic ant s U. S. Pat. N o . 5, 3 3 6, 4 99 w hic h
disc l o ses the destr u c tio n and inhib itio n o f b ac ter ia, al g ae
and the AI DS v ir u s in nu tr ient l if e su p p o r ting system s b y
u sing said sil v er o x ide dev ic es. Ex am p l e 3 o f said p atent
disc l o ses that 1 8 PPMo f said c r ystal dev ic es c o u l d to tal l y
su p p r ess the AI DS v ir u s ( p ag e 6. l ine 5) . Su b seq u ent to the
? l ing o f the af o r em entio ned p atent, f u r ther testing r ev eal ed
c o m p l ete 1 0 0 % destr u c tio n o f the AI DS v ir u s in v itr o at 2 0
PPM, and the f ac t that said dev ic es w er e har m l ess w hen
ing ested and inhal ed, b eing no n- to x ic .
Enc o u r ag ed b y these ev al u atio ns and su c c esses, ap p l ic ant
o b tained p er m issio n to ev al u ate the c r ystal s in v itr o ag ainst
m u r ine ac q u ir ed im m u ne de? c ienc y syndr o m e ( MAI DS) .
Onl y o ne f ac il ity in the State o f I sr ael is l ic ensed f o r these
ev al u atio ns, nam el y, the Kap l an Ho sp ital in Reho v o t, I sr ael ,
w hic h is af ? l iated w ith the Heb r ew Univ er sity- Hadassah
Medic al Sc ho o l w her e said ev al u atio ns w er e do ne.
The initial ev al u atio ns entail ed ex p er im enting w ith v ar i
o u s sil v er m o ieties c ited in ap p l ic ant s af o r em entio ned
p atent, c o nc entr atio ns, no n- r eac tiv e b u f f er s and m o des o f
adm inistr atio n. Af ter ab o u t 1 8 m o nths o f j u dic io u s ef f o r ts
and initial f ail u r es, su c c ess w as ? nal l y ac hiev ed in destr o y
ing the MAI DS v ir u s in C57BLm ic e w ith a sing l e intr av e
no u s inj ec tio n. The r esu l ts o f this test p r o g r am c o m p r ise
Ex am p l e 5 o f U. S. Pat. N o . 5, 3 3 6, 4 99. Af ter su c c ess w ith
m ic e, the inv ento r w as ab l e to test the e? ic ac y o f said
dev ic es o n tw o sel ec t etio l o g ic al g r o u p s o f ter m inal AI DS
p atients in a c l inic in Teg u c ig al p a, Ho ndu r as, Centr al
Am er ic a.
The AI DS p atients c o m p r ised the etio l o g ic al su b g r o u p s,
Candidiasis and Wasting Syndr o m e. Cu r r ent indic ato r dis
eases f o r diag no sing AI DS w hic h hav e b een ex p anded b y
the CDC, f al l into the f o l l o w ing ? v e m aj o r c ateg o r ies w ith
the ap p r o x im ate p er c ent distr ib u tio n am o ng AI DS p atients:
1 . P. c ar inii p neu m o nia 51 %
2 . Wasting syndr o m e 1 9%
3 . Candidiasis 1 3 %
4 . Kap o si s sar c o m a 1 1 %
5. Dem entia 6%
This inv entio n c o nc er ns itsel f w ith the tr eatm ent and c u r e
o f c andidiasis and w asting syndr o m e AI DS p atients w ith
1 0
2 0
2 5
3 5
50
55
65
2
Tetr asil l . These tw o g r o u p s ac c o u nt f o r ap p r o x im atel y o ne
thir d o f AI DS c ases.
* Tr adem ar k o f Ho l ip har m Co r p o r atio n ( o f I sr ael ) f o r Ag 4 O4
Stedm an s Medic al Dic tio nar y ( Wil l iam s & Wil k en s
2 6th Ed, 1 995) de? nes w asting syndr o m e as a c o nditio n o f
1 0 % w eig ht l o ss in c o nj u nc tio n w ith diar r hea o r f ev er . . .
Asso c iated w ith AI DS ( p . 1 74 4 ) .
OBI ECI ' S OFTHEI N VEN TI ON
The m ain o b j ec t o f the inv entio n is to p r o v ide f o r a
m o l ec u l ar sc al e dev ic e o f a sing l e tetr asil v er tetr o x ide
c r ystal l ine m o l ec u l e c ap ab l e o f r esto r ing the im m u nity o f
AI DS af f l ic ted hu m ans o f the tw o AI DS etio l o g ic al
su b g r o u p s, c andidiasis and w asting syndr o m e.
Ano ther o b j ec t o f the inv entio n is to p r o v ide f o r im m u nity
r esto r atio n in said AI DS atf l ic ted hu m ans thr o u g h a sing l e
inj ec tio n.
Ano ther o b j ec t o f this inv entio n is to destr o y I SM in
hu m ans m anif esting AI DS diseases o f said AI DS etio l o g ic al
su b g r o u p s ir r esp ec tiv e as to w hether said I SMw as HI V
indu c ed, sinc e it is k no w n that hu m ans m ay m anif est AI DS
and stil l b e HI V neg ativ e, and thu s r esto r e the im m u ne
system in said hu m ans.
Ano ther o b j ec t o f this inv entio n is to destr o y the AI DS
v ir u s w hen p r esent in the system s o f said AI DS a? l ic ted
hu m ans.
SUMI VI ARY OFTHEI N VEN TI ON
This inv entio n r el ates to a m o l ec u l ar sc al e dev ic e no t o nl y
c ap ab l e o f destr o ying the AI DS v ir u s, b u t o f p u r g ing the
hu m an b l o o dstr eam o f p atho g ens and r esto r ing im m u nity to
AI DS p atients o f the c andidiasis and w asting syndr o m e
c ateg o r ies. Said m o l ec u l ar dev ic e c o nsists o f a sing l e c r ystal
o f tetr asil v er tetr o x ide ( Ag 4 O4 ) . The c r ystal l attic e o f this
m o l ec u l e has a u niq u e str u c tu r e sinc e it is a diam ag netic
sem ic o ndu c ting c r ystal c o ntaining tw o m o no and tw o tr iv a
l ent sil v er io ns, w hic h in eiI ec t ar e c ap ab l e o f ? r ing
el ec tr o ns u nder c er tain c o nditio ns w hic h w il l destr o y AI DS
v ir u ses, o ther p atho g ens and im m u ne su p p r essing m o ieties
( I SM) , no t o nl y thr o u g h the el ec tr o c u tio n m o de, b u t al so b y
a b inding p r o c ess w hic h o c c u r s sim u l taneo u sl y w ith el ec tr o n
? r ing , nam el y, b inding and c hel atio n o f div al ent sil v er , i. e. ,
the r esu l ting p r o du c t o f the el ec tr o n tr ansf er r edo x that o c c u r
w hen the m o no v al ent sil v er io ns ar e o x idiz ed and the
tr iv al ent io ns ar e r edu c ed in the c r ystal . The b inding /
c hel atio n ef f ec t o c c u r s at ac tiv e sites o f the AI DS v ir u s.
p atho g ens and I SM. Bec au se o f the ex tr em el y m inu te siz e o f
a sing l e m o l ec u l e o f this c r ystal , sev er al m il l io n o f these
dev ic es m ay b e em p l o yed in c o nc er t to destr o y a v ir u s
c o l o ny to p u r g e a l if e su p p o r t system o f I SMand p atho g ens
w ith the c o nsu m p tio n o f o nl y p ar ts p er tr il l io n o f the c r ystal
dev ic es. Thu s an o p tim u m o f 4 0 PPMo f the dev ic es b y
w eig ht o f hu m an b l o o d w as f o u nd to b e su ? ic ient to c o m
p l etel y o b l iter ate AI DS. This c o nc entr atio n is sl ig htl y o v er
do u b l e o f the o p tim u m c o nc entr atio n r ec o m m ended in ap p l i
c ant s af o r em entio ned US. p atent f o r the destr u c tio n o f the
hu m an AI DS v ir u s in v itr o . Other detail s c o nc er ning the
str u c tu r e o f the c r ystal and its m ec hanism ag ainst p atho g ens,
the AI DS v ir u s and I SMw o u l d anal o g o u sl y ho l d her e, and
hav e al r eady b een f u r ther el u c idated in said p atent.
The ac tu al destr u c tio n o f p atho g ens. I SMand the AI DS
v ir u s is e? ec tu ated b y inj ec tio n o f a su sp ensio n o f these
dev ic es in distil l ed o r deio niz ed w ater w ith a no n- r eac ting
el ec tr o l yte dir ec tl y, i. e. intr av eno u sl y, into the b l o o dstr eam .
A sing l e inj ec tio n is al l that is r eq u ir ed u nder these c o ndi
tio ns. Ac c o r ding l y, hu m ans inj ec ted in this m anner , u p o n
5, 676, 977
3
b eing insp ec ted af ter thr ee w eek s o r m o r e had el ap sed and
c o m p ar ed w ith sim il ar hu m ans that had b een g iv en
p l ac eb o s, w er e c o m p l etel y c u r ed o f AI DS. The c o ntr o l
g r o u p stil l m anif ested AI DS. Ac c o r ding l y, the tetr asil v er
ten- o x ide dev ic e p er f o r m ed in c o nc er t w ith and in f u l l
c o nf o r m ity w ith the u l tim ate o b j ec ts o f this inv entio n.
Fu r ther m o r e, thr ee o u t o f f o u r w asting syndr o m e ter m inal
p atients and f o u r o u t o f the ? v e c andidiasis ter m inal p atients
w er e stil l al iv e in 1 995 af ter a year and a hal f had el ap sed
f r o m their initial inj ec tio n. By that tim e al l the AI DS p atients
had b een r el eased f r o m the c l inic and al l o w ed to r etu r n
ho m e.
Other o b j ec ts and f eatu r es o f the p r esent inv entio n shal l
b ec o m e ap p ar ent to tho se sk il l ed in the ar t w hen the p r esent
inv entio n is c o nsider ed in v iew o f the ac c o m p anying
ex am p l es. I t sho u l d, o f c o u r se, b e r ec o g niz ed that the
ac c o m p anying ex am p l es il l u str ate p r ef er r ed em b o dim ents o f
the p r esent inv entio n and ar e no t intended as a m eans o f
de? ning the l im its and sc o p e o f the p r esent inv entio n.
EXAMPLE1
Fiv e p atients af f l ic ted w ith AI DS o f the c andidiasis etio
l o g ic al c ateg o r y w er e seg r eg ated f o r Tetr asil tr eatm ent. The
r atio nal e f o r sel ec ting them w as b ased o n f ac ts p r esented in
an ar tic l e b y Peter H. Du esb er g and Br ian J . El l iso n entitl ed
I s The AI DS Vir u s A Sc ienc e Fic tio n? ( Po l ic y Rev iew ,
Su m m er 1 990 p p . 4 0 - 51 ) . Onl y the f ac tu al p r esentatio ns o f
the ar tic l e w er e u til iz ed and the hyp o thesis o f the au tho r s
w as ig no r ed. The f ac ts p r esented in the ar tic l e r el ated to the
m etho d o f sel ec ting AI DS p atients b ased o n the ? v e af o r e
m entio ned etio l o g ic al su b g r o u p s tar g eted b y the CDC, and
the ev idenc e p r esented, that ther e is AI DS w itho u t I - HV as
w el l as w ith it so that an anti- v ir al ag ent in m o st instanc es
w il l no t nec essar il y r esto r e the im m u nity system .
Ev al u atio ns w ith Tetr asil w er e c o ndu c ted o n AI DS
p atients at Lu c ha Co ntr a el Sida. Co m ayag u c l a. Ho ndu r as.
The p atients tw o w eek s p r io r to ino c u l atio n w er e r em o v ed
f r o m their AZT, AI DS ther ap y. Tetr asil w as adm inister ed at
ap p r o x im atel y 4 0 PPMo f b l o o d v o l u m e p er p atient as a
su sp ensio n in a p r o p r ietar y b u ? er so l u tio n ( p H= 6. 5) , su p
p l ied b y Ho l ip har m Co r p o r atio n.
The r esu l ts o f ev al u atio ns w ith c andidiasis ar e tab u l ated
in Tab l e I u nder its disease c ateg o r y. Al l p atients ev al u ated
w er e ter m inal . So m e, ho w ev er , w er e in m o der ate ( I n) c o n
ditio n and o ther s in p o o r ( p ) as desig nated in the Tab l e. The
I and Fdesig natio ns r ef er to initial and ? nal v al u es as sho w n.
WBC indic ates w hite c el l b l o o d c o u nt. The H c o l u m n,
f o l l o w ing CD 8 , indic ates w hether hep ato m eg al y o c c u r r ed
1 5
2 0
3 5
4 5
4
This w as an u nf o r tu nate c o nseq u enc e o f the tr eatm ent w hic h
r esu l ted in enl ar g ed l iv er s in al l p atients ex c ep t the sec o nd
o ne. Desp ite hep ato m eg al y, ther e w as no inter f er enc e w ith
l iv er f u nc tio n.
The o nset o f hep ato m eg al y w as no t sp o ntaneo u s and
v ar ied f r o m p atient to p atient, b eing in the r ang e o f 4 - 1 6
days.
I t sho u l d al so b e no ted that sho r tl y af ter inj ec tio n o f
Tetr asil ther e w er e indic atio ns o f f ev er ( sym b o l iz ed b y Tin
the Ag 4 O4 c o l u m n) , so m etim es ac c o m p anied b y f atig u e ( F) .
The b o dy tem p er atu r e w as inv ar iab l y 3 8 5 C. ( 1 0 l . 3 F. ) .
This w as indic ativ e o f r esto r atio n o f the im m u ne r esp o nse o f
the b o dy, sinc e no r m al l y the b o dy w il l destr o y p atho g ens
w hen the im m u ne system is f u nc tio nal b y r aising the tem
p er atu r e. The p atient w ho died; ? r st r esp o nded f av o r ab l y to
Di? u c an, w hic h p r ev io u sl y g av e no r esp o nse. He w as c u r ed
o f his c andidiasis, b u t u nf o r tu natel y su c c u m b ed to his p r e
v io u s b o dy dam ag e. Al l the o ther c andidiasis syndr o m e
p eo p l e w ho p r ev io u sl y did no t r esp o nd to the indic ated
m edic atio ns su b seq u entl y r esp o nded af ter the Tetr asil tr eat
m ent. Fu r ther ev idenc e o f the r ec o v er y o f the AI DS p atients
m anif ested itsel f 3 0 days af ter the initial inj ec tio n w hen
w hite b l o o d c el l c o u nts w er e tak en. They ar e sho w n in Tab l e
I u nder the WBCc o l u m n, w hic h g iv es the initial and ? nal
WBC. Al l c andidiasis p atients sho w ed a dr am atic inc r ease in
their w hite b l o o d c el l c o u nts, indic ativ e o f the r esto r atio n o f
their im m u nity system s.
EXAMPLE2
The ab o v e p r o to c o l o f Ex am p l e 1 w as r ep eated w ith AI DS
p atients ex hib iting w asting syndr o m e. The r esu l ts o f their
tr eatm ent ar e tab u l ated in Tab l e I u nder the disease c ateg o r y
o f said syndr o m e. I t sho u l d b e no ted that tw o o f the f o u r
w asting syndr o m e p atients sho w ed im p r o v ed w hite b l o o d
c o u nts. The f em al e p atient, w ho se c o nditio n im p r o v ed f r o m
p o o r and ter m inal to b e am o ng the l iv ing , sho w ed a dec r ease
in the WBC. Ho w ev er , she sho w ed an inc r ease in b o dy
tem p er atu r e w hic h w as indic ativ e o f im m u ne r esp o nse. The
test r esu l ts indic ate that o ne c anno t r el y o n a sing l e f ac to r to
indic ate the dem ise o f AI DS. The u su al I { [ V m ar k er CD 4
initial and ? nal ar e ir r el ev ant. I SMsu p p r essio n ap p ear s to b e
m o r e c r itic al than the destr u c tio n o f HI V. AI DS w as
su p p r essed, any p er m anent dam ag e that had b een do ne to the
p atients in the c o u r se o f their su c c u m b ing to AI DS w as no t
o b v io u sl y c u r ed o r c o r r ec ted b y said c r ystal dev ic e
tr eatm ent, r ather said inj u r y p er sisted and the p atient w as
im p r o v ed w ith r esp ec t to AI DS b u t stil l su ? er ed f r o m said
p er m anent inj u r y o r im p air m ent p r ev io u sl y in? ic ted.
TABLEI
Rem nse o f AI DS Patients to Sm g l e 4 0 PPMAg I OI I no c u l atio n
Date Weig ht
DI SEASE PATI EN T I no c . WBC CD 4 DEATH Lb s.
Gr o u p Sex Ag e Medic m 1 994 I F I F CD 8 H 1 94 4 I F Ag , , 0 4
Candidiasis Mp 2 8 Di? u c an 5/ 5 1 , 2 0 0 4 , 2 0 0 4 1 2 2 1 + 6/ 1 1 8 2 76 T
Fm 3 3 " 5/ 5 6, 0 0 0 6, 70 0 554 8 72 3 94 98 98 T
Fm 3 3 Ketac o nz l 5/ 2 7 2 , 60 0 3 , 8 50 2 4 8 1 8 1 951 + 1 2 3 1 2 3 T
Mp 62 " 6/ 2 3 , 3 0 0 3 , 70 0 8 9 2 3 7 59 + 1 0 5 92 F
Fm 3 1 Pentam idn 6/ 2 2 , 4 0 0 3 , 0 50 9 1 8 1 65 + 1 2 1 1 1 8 Pain
Wasting Mm 2 7 5/ 2 7 3 , 60 0 4 , 60 0 3 9 1 4 70 9 + 1 1 9 1 2 0 T
Syndr o m e Mm 2 8 5/ 2 7 2 , 750 1 D - 60 + 7/ 1 9 1 2 1 1 1 9 T, F
Fp 4 3 5/ 2 7 3 , 60 0 2 , 70 0 68 2 4 6 2 4 8 + 1 0 1 98 T, F
Mm 1 9 5/ 1 0 3 , 8 50 5, 4 0 0 1 3 7 3 6 4 8 + 1 0 3 1 0 6 T, F
5, 676, 977
5
As this inv entio n m ay b e em b o died in sev er al f o r m s
w itho u t dep ar ting f r o m the sp ir it o r essential c har ac ter istic s
ther eo f , the p r esent em b o dim ents ar e ther ef o r e il l u str ativ e
and no t r estr ic tiv e, sinc e the sc o p e o f the inv entio n is de? ned
b y the ap p ended c l aim s r ather than b y the desc r ip tio n
p r ec eding them , and al l c hang es that f al l w ithin the m etes
and b o u nds o f the c l aim s o r that f o r m their f u nc tio nal as w el l
as c o nj o intl y c o o p er ativ e eq u iv al ents, ar e ther ef o r e intended
to b e em b r ac ed b y these c l aim s.
What is c l aim ed is:
1 . A m etho d o f tr eating AI DS- af f l ic ted hu m ans c o m p r is
ing inj ec ting a m u l titu de o f tetr asil v er tetr o x ide m o l ec u l ar
c r ystal s into the b l o o dstr eam o f the hu m an su b j ec t.
1 0
6
2 . A m etho d f o r inc r easing w hite b l o o d c el l c o u nts in
Al DS- a? l ic ted hu m ans c o m p r ising inj ec ting a m u l titu de o f
tetr asil v er tetr o x ide m o l ec u l ar c r ystal s into the b l o o dstr eam
o f the hu m an su b j ec t.
3 . Metho ds o f tr eating AI DS- a? il ic ted hu m ans ac c o r ding
to c l aim s 1 - 2 w her e the c o nc entr atio n o f said m o l ec u l ar
c r ystal s is ap p r o x im atel y 4 0 PPMo f the to tal b l o o d w eig ht
o f the hu m an su b j ec t.