Version: 3.

10
Revision Date: 10-13-2020

SAFETY DATA SHEET

According to US Regulation 29 CFR 1910.1200 (HazCom 2012)

1. Identification

Product identifier: Acetone

Other means of identification

Synonyms: 2-Propanone
Product No.: 2432, 2435, 2437, 2440, 2443, 2462, 2570, 2572, 5008, 5018,
5276, 5356, 5580, 5965, 5975, 9002, 9003, 9005, 9006, 9008,
9009, 9010, 9015, 9036, 9254, 9271, 9422, A134, H451, H580,
10444, 10654, 12264, 63842, 70444

Recommended restrictions
Recommended use: For Laboratory, Research or Manufacturing Use.
Restrictions on use: Not determined.

Details of the supplier of the safety data sheet

Company Name: Avantor Performance Materials, LLC

Address: 100 Matsonford Rd, Suite 200
Radnor, PA 19087

Telephone: Customer Service: 855-282-6867

Contact Person: Product Information Compliance

E-mail: info@avantormaterials.com

Emergency telephone number:

CHEMTREC: 1-800-424-9300 within US and Canada (24 hrs/day, 7 days/week)

2. Hazard(s) identification

Hazard Classification
Physical Hazards
Flammable liquids Category 2
Health Hazards
Serious Eye Damage/Eye Irritation Category 2A
1.
Specific Target Organ Toxicity - Category 3
Single Exposure
Aspiration Hazard Category 2

Target Organs
1. Narcotic effect.

Label Elements

Hazard Symbol:

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Signal Word: Danger

Hazard Statement: Highly flammable liquid and vapor.

Causes serious eye irritation.
May cause drowsiness or dizziness.
May be harmful if swallowed and enters airways.

Precautionary
Statements

Prevention: Keep away from heat, hot surfaces, sparks, open flames and other ignition
sources. No smoking. Keep container tightly closed. Use explosion-proof
[electrical/ventilating/lighting] equipment. Ground and bond container and
receiving equipment. Use non-sparking tools. Take action to prevent static
discharges. Wash thoroughly after handling. Avoid breathing
dust/mist/vapors/spray. Use only outdoors or in a well-ventilated area.

Response: In case of fire: Use water spray, foam, dry powder or carbon dioxide for
extinction. IF ON SKIN (or hair): Take off immediately all contaminated
clothing. Rinse skin with water [or shower]. IF IN EYES: Rinse cautiously
with water for several minutes. Remove contact lenses, if present and easy
to do. Continue rinsing. If eye irritation persists: Get medical
advice/attention. IF INHALED: Remove person to fresh air and keep
comfortable for breathing. Call a POISON CENTER/doctor if you feel
unwell. IF SWALLOWED: Immediately call a POISON CENTER/doctor. Do
NOT induce vomiting.

Storage: Store in a well-ventilated place. Keep cool. Store locked up.

Disposal: Dispose of contents/container to an appropriate treatment and disposal

facility in accordance with applicable laws and regulations, and product
characteristics at time of disposal.

Hazard(s) not otherwise Static accumulating flammable liquid can become electrostatically charged
classified (HNOC): even in bonded and grounded equipment. Sparks may ignite liquid and
vapor. May cause flash fire or explosion.

3. Composition/information on ingredients

Substances

Chemical Identity CAS number Content in percent (%)*

Acetone 67-64-1 99.00 - 100.00%

* All concentrations are percent by weight unless ingredient is a gas. Gas concentrations are in percent by volume.

4. First-aid measures

General information: Get medical advice/attention if you feel unwell. Show this safety data sheet
to the doctor in attendance.

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Ingestion: Call a physician or poison control center immediately. Do NOT induce

vomiting. If vomiting occurs, keep head low so that stomach content doesn't
get into the lungs.

Inhalation: Move to fresh air. Get medical attention if symptoms persist.

Skin Contact: Immediately flush with plenty of water for at least 15 minutes while
removing contaminated clothing and shoes. Get medical attention if
symptoms occur. Wash contaminated clothing before reuse. Destroy or
thoroughly clean contaminated shoes.

Eye contact: Immediately flush with plenty of water for at least 15 minutes. If easy to do,
remove contact lenses. Get medical attention if irritation persists after
washing.

Most important symptoms/effects, acute and delayed

Symptoms: Narcotic effect.

Hazards: None known.

Indication of immediate medical attention and special treatment needed

Treatment: Symptoms may be delayed. Treat symptomatically.

5. Fire-fighting measures

General Fire Hazards: Flammable liquid and vapor.

Suitable (and unsuitable) extinguishing media

Suitable extinguishing Water spray, foam, dry powder or carbon dioxide.

media:

Unsuitable extinguishing Avoid water in straight hose stream; will scatter and spread fire.
media:

Specific hazards arising from Vapors may cause a flash fire or ignite explosively. Vapors may travel
the chemical: considerable distance to a source of ignition and flash back. Prevent
buildup of vapors or gases to explosive concentrations. Heat may cause the
containers to explode.

Special protective equipment and precautions for firefighters

Special fire fighting Use water spray to keep fire-exposed containers cool. Water may be
procedures: ineffective in fighting the fire. Fight fire from a protected location. Move
containers from fire area if you can do so without risk.

Special protective equipment Firefighters must use standard protective equipment including flame
for fire-fighters: retardant coat, helmet with face shield, gloves, rubber boots, and in
enclosed spaces, SCBA.

6. Accidental release measures

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Personal precautions, See Section 8 of the SDS for Personal Protective Equipment. Do not touch
protective equipment and damaged containers or spilled material unless wearing appropriate
emergency procedures: protective clothing. Keep unauthorized personnel away. Ventilate closed
spaces before entering them. ELIMINATE all ignition sources (no smoking,
flares, sparks or flames in immediate area). Keep upwind.

Methods and material for In case of leakage, eliminate all ignition sources. Take precautionary
containment and cleaning measures against static discharges. Stop leak if possible without any risk.
up: Use non-sparking tools. Absorb spill with vermiculite or other inert material,
then place in a container for chemical waste. Clean surface thoroughly to
remove residual contamination. Dike far ahead of larger spill for later
recovery and disposal.

Notification Procedures: Inform authorities if large amounts are involved.

Environmental Precautions: Do not contaminate water sources or sewer. Prevent further leakage or
spillage if safe to do so.

7. Handling and storage

Precautions for safe handling: DO NOT handle, store or open near an open flame, sources of heat or
sources of ignition. Protect material from direct sunlight. Take precautionary
measures against static discharges. Ground and bond container and
receiving equipment. Use personal protective equipment as required. Do
not get in eyes, on skin, on clothing. Use only with adequate ventilation.
Wash hands thoroughly after handling. Do not handle until all safety
precautions have been read and understood. Obtain special instructions
before use.

Conditions for safe storage, Keep away from food, drink and animal feeding stuffs. Keep container
including any tightly closed in a cool, well-ventilated place. Ground container and transfer
incompatibilities: equipment to eliminate static electric sparks. Comply with all national, state,
and local codes pertaining to the storage, handling, dispensing, and
disposal of flammable liquids.

8. Exposure controls/personal protection

Control Parameters
Occupational Exposure Limits
Chemical Identity Type Exposure Limit Values Source

Acetone TWA 250 ppm US. ACGIH Threshold Limit Values (03 2015)
STEL 500 ppm US. ACGIH Threshold Limit Values (03 2015)
REL 250 ppm 590 mg/m3 US. NIOSH: Pocket Guide to Chemical
Hazards (2010)
PEL 1,000 ppm 2,400 mg/m3 US. OSHA Table Z-1 Limits for Air
Contaminants (29 CFR 1910.1000) (02 2006)
TWA 750 ppm 1,800 mg/m3 US. OSHA Table Z-1-A (29 CFR 1910.1000)
(1989)
STEL 1,000 ppm 2,400 mg/m3 US. OSHA Table Z-1-A (29 CFR 1910.1000)
(1989)
TWA 750 ppm 1,800 mg/m3 US. Tennessee. OELs. Occupational Exposure
Limits, Table Z1A (06 2008)
Ceiling 3,000 ppm US. California Code of Regulations, Title 8,
Section 5155. Airborne Contaminants (08
2010)
STEL 750 ppm 1,780 mg/m3 US. California Code of Regulations, Title 8,
Section 5155. Airborne Contaminants (08
2010)
TWA PEL 500 ppm 1,200 mg/m3 US. California Code of Regulations, Title 8,
Section 5155. Airborne Contaminants (08
2010)
STEL 1,000 ppm 2,400 mg/m3 US. Tennessee. OELs. Occupational Exposure
Limits, Table Z1A (01 2019)
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ST ESL Health 3,300 ppb US. Texas. Effects Screening Levels (Texas
Commission on Environmental Quality) (06
2018)
AN ESL Health 4,800 µg/m3 US. Texas. Effects Screening Levels (Texas
Commission on Environmental Quality) (06
2018)
ST ESL Health 7,800 µg/m3 US. Texas. Effects Screening Levels (Texas
Commission on Environmental Quality) (06
2018)
AN ESL Health 2,000 ppb US. Texas. Effects Screening Levels (Texas
Commission on Environmental Quality) (06
2018)

Biological Limit Values

Chemical Identity Exposure Limit Values Source
Acetone (acetone: Sampling 25 mg/l (Urine) ACGIH BEI (03 2015)
time: End of shift.)

Appropriate Engineering No data available.

Controls

Individual protection measures, such as personal protective equipment

General information: Good general ventilation (typically 10 air changes per hour) should be used.
Ventilation rates should be matched to conditions. If applicable, use
process enclosures, local exhaust ventilation, or other engineering controls
to maintain airborne levels below recommended exposure limits. If
exposure limits have not been established, maintain airborne levels to an
acceptable level. An eye wash and safety shower must be available in the
immediate work area. Use explosion-proof ventilation equipment.

Eye/face protection: Wear safety glasses with side shields (or goggles) and a face shield.

Skin Protection
Hand Protection: Chemical resistant gloves

Other: Wear suitable protective clothing and gloves.

Respiratory Protection: In case of inadequate ventilation use suitable respirator. Chemical

respirator with organic vapor cartridge.

Hygiene measures: Provide eyewash station and safety shower. Observe good industrial
hygiene practices. Do not eat, drink or smoke when using the product.
Wash hands before breaks and immediately after handling the product.
Wash contaminated clothing before reuse. Do not get this material in
contact with skin. Avoid contact with eyes. Do not handle until all safety
precautions have been read and understood. Obtain special instructions
before use.

9. Physical and chemical properties

Appearance
Physical state: Liquid
Form: Liquid
Color: Colorless
Odor: Sweet, mint-like
Odor threshold: No data available.
pH: 5 - 6 (20 °C)
Melting point/freezing point: -94.8 - 94.6 °C
Initial boiling point and boiling range: 56 °C (101.3 kPa)
Flash Point: -20 - -17 °C (Closed Cup)
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Evaporation rate: No data available.

Flammability (solid, gas): Class IB Flammable Liquid
Upper/lower limit on flammability or explosive limits
Flammability limit - upper (%): 12.8 %(V)
Flammability limit - lower (%): 2.13 - 2.6 %(V)
Explosive limit - upper (%): No data available.
Explosive limit - lower (%): No data available.
Vapor pressure: 233 - 240 hPa (20 °C) 309 hPa (25 °C) 530 - 560 hPa (40 °C)
Vapor density: 2
Density: 0.79 g/ml (20 °C)
Relative density: 0.80 (20 °C)
Solubility(ies)
Solubility in water: Miscible
Solubility (other): Alcohol: Miscible
benzene: Soluble
chloroform: Miscible
dimethylformamide: Miscible
ether: Miscible
Partition coefficient (n-octanol/water): -0.24
Auto-ignition temperature: 465 °C
Decomposition temperature: No data available.
Viscosity: No data available.

Other information
Liquid conductivity: 0.6 µS/cm (25 °C)
Minimum ignition energy: 1.15 mJ
Molecular weight: 58.08 g/mol ((CH₃)₂CO)

10. Stability and reactivity

Reactivity: No dangerous reaction known under conditions of normal use.

Chemical Stability: Material is stable under normal conditions.

Possibility of hazardous Hazardous polymerization does not occur.

reactions:

Conditions to avoid: Heat, sparks, flames. Contact with incompatible materials.

Incompatible Materials: Strong acids. Strong oxidizing agents.

Hazardous Decomposition Thermal decomposition may release oxides of carbon.

Products:

11. Toxicological information

Information on likely routes of exposure

Inhalation: May cause irritation to the respiratory system.

Skin Contact: Prolonged skin contact may cause temporary irritation.

Eye contact: Causes serious eye irritation.

Ingestion: May cause irritation of the gastrointestinal tract.

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Information on toxicological effects

Acute toxicity (list all possible routes of exposure)

Oral
Product: LD 50 (Rat): 5,800 mg/kg

Dermal
Product: LD 50 (Rabbit) 20,000 mg/kg

Inhalation
Product: LC 50 (Rat, 4 h) 50.1 - 76 mg/l

Repeated dose toxicity

Product: No data available.

Skin Corrosion/Irritation
Product: Prolonged skin contact may cause temporary irritation.

Serious Eye Damage/Eye Irritation

Product: Causes serious eye irritation.

Respiratory or Skin Sensitization

Product: Not a skin nor a respiratory sensitizer.

Carcinogenicity
Product: This substance has no evidence of carcinogenic properties.

IARC Monographs on the Evaluation of Carcinogenic Risks to Humans:

No carcinogenic components identified

US. National Toxicology Program (NTP) Report on Carcinogens:

No carcinogenic components identified

US. OSHA Specifically Regulated Substances (29 CFR 1910.1001-1050):

No carcinogenic components identified

Germ Cell Mutagenicity

In vitro
Product: No mutagenic components identified

In vivo
Product: No mutagenic components identified

Reproductive toxicity
Product: No components toxic to reproduction

Specific Target Organ Toxicity - Single Exposure

Product: Narcotic effect.

Specific Target Organ Toxicity - Repeated Exposure

Product: None known.

Target Organs
Specific Target Organ Toxicity - Single Exposure: Narcotic effect.

Aspiration Hazard

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Product: May be harmful if swallowed and enters airways.

Other effects: None known.

12. Ecological information

Ecotoxicity:

Acute hazards to the aquatic environment:

Fish
Product: LC 50 (Fathead minnow (Pimephales promelas), 96 h): 5,490 - 7,030 mg/l
Mortality
LC 50 (Bluegill (Lepomis macrochirus), 96 h): 8,300 mg/l Mortality

Aquatic Invertebrates
Product: LC 50 (Brine shrimp (Artemia salina), 24 h): 2,100 mg/l Mortality
LC 50 (Water flea (Daphnia magna), 48 h): 12,100 mg/l Mortality

Chronic hazards to the aquatic environment:

Fish
Product: No data available.

Aquatic Invertebrates
Product: No data available.

Toxicity to Aquatic Plants

Product: No data available.

Persistence and Degradability

Biodegradation
Product: Expected to be readily biodegradable.

BOD/COD Ratio
Product: No data available.

Bioaccumulative potential
Bioconcentration Factor (BCF)
Product: No data available on bioaccumulation.

Partition Coefficient n-octanol / water (log Kow)

Product: Log Kow: -0.24

Mobility in soil: No data available.

Other adverse effects: The product components are not classified as environmentally hazardous.
However, this does not exclude the possibility that large or frequent spills
can have a harmful or damaging effect on the environment.

13. Disposal considerations

Disposal instructions: Discharge, treatment, or disposal may be subject to national, state, or local
laws.

Contaminated Packaging: Since emptied containers retain product residue, follow label warnings even
after container is emptied.
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14. Transport information

DOT
UN Number: UN 1090
UN Proper Shipping Name: Acetone
Transport Hazard Class(es)
Class: 3
Label(s): 3
Packing Group: II
Marine Pollutant: No
Special precautions for user: Not determined.

IMDG
UN Number: UN 1090
UN Proper Shipping Name: ACETONE
Transport Hazard Class(es)
Class: 3
Label(s): 3
EmS No.: F-E, S-D
Packing Group: II
Marine Pollutant: No
Special precautions for user: Not determined.

IATA
UN Number: UN 1090
Proper Shipping Name: Acetone
Transport Hazard Class(es):
Class: 3
Label(s): 3
Packing Group: II
Marine Pollutant: No
Special precautions for user: Not determined.

15. Regulatory information

US Federal Regulations
TSCA Section 12(b) Export Notification (40 CFR 707, Subpt. D)
None present or none present in regulated quantities.

US. OSHA Specifically Regulated Substances (29 CFR 1910.1001-1050)

None present or none present in regulated quantities.

CERCLA Hazardous Substance List (40 CFR 302.4):

Chemical Identity Reportable quantity
Acetone 5000 lbs.

Superfund Amendments and Reauthorization Act of 1986 (SARA)

Hazard categories
Flammable (gases, aerosols, liquids, or solids)
Serious eye damage or eye irritation
Specific target organ toxicity (single or repeated exposure)
Aspiration Hazard

SARA 302 Extremely Hazardous Substance

None present or none present in regulated quantities.

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SARA 304 Emergency Release Notification

None present or none present in regulated quantities.

SARA 311/312 Hazardous Chemical

Chemical Identity Threshold Planning Quantity
Acetone 10000 lbs.

SARA 313 (TRI Reporting)

None present or none present in regulated quantities.

Clean Air Act (CAA) Section 112(r) Accidental Release Prevention (40 CFR 68.130):
None present or none present in regulated quantities.

Clean Water Act Section 311 Hazardous Substances (40 CFR 117.3):
None present or none present in regulated quantities.

US State Regulations

US. California Proposition 65

No ingredient requiring a warning under CA Prop 65.

US. New Jersey Worker and Community Right-to-Know Act

Chemical Identity
Acetone

US. Massachusetts RTK - Substance List

Chemical Identity
Acetone

US. Pennsylvania RTK - Hazardous Substances

Chemical Identity
Acetone

US. Rhode Island RTK

Chemical Identity
Acetone

International regulations

Montreal protocol
Not applicable

Stockholm convention
Not applicable

Rotterdam convention
Not applicable

Kyoto protocol
Not applicable

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Inventory Status:
Australia AICS: On or in compliance with the inventory
Canada DSL Inventory List: On or in compliance with the inventory
China Inv. Existing Chemical Substances: On or in compliance with the inventory
Japan (ENCS) List: On or in compliance with the inventory
Japan ISHL Listing: Not in compliance with the inventory.
Korea Existing Chemicals Inv. (KECI): On or in compliance with the inventory
Mexico INSQ: On or in compliance with the inventory
New Zealand Inventory of Chemicals: On or in compliance with the inventory
Philippines PICCS: On or in compliance with the inventory
Taiwan Chemical Substance Inventory: On or in compliance with the inventory
US TSCA Inventory: On or in compliance with the inventory
EINECS, ELINCS or NLP: On or in compliance with the inventory

16.Other information, including date of preparation or last revision

NFPA Hazard ID

3 Flammability
Health
1 0
Reactivity
Special hazard.

Hazard rating: 0 - Minimal; 1 - Slight; 2 - Moderate; 3 - Serious; 4 - Severe; RNP - Rating not possible

Issue Date: 10-13-2020

Revision Information: Not relevant.

Version #: 3.10

Source of information: Sources of information used in preparing this SDS included one or more of
the following: results from in house or supplier toxicology studies, information
from the Toxicology Data Network (TOXNET), European Chemical Agency
(ECHA) substance dossiers, IARC Monographs, US National Toxicology
Program data, the Agency for Toxic Substances and Disease Registry, other
manufacturer’s SDSs and other sources, as appropriate.

Further Information: No data available.

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Disclaimer: The information provided in this Safety Data Sheet (SDS) was prepared
based on data believed to be accurate as of the date of this SDS. TO THE
GREATEST EXTENT PERMITTED BY LAW, AVANTOR PERFORMANCE
MATERIALS (“AVANTOR”) EXPRESSLY DISCLAIMS ANY AND ALL
REPRESENTATIONS AND WARRANTIES REGARDING THE
INFORMATION CONTAINED HEREIN INCLUDING, WITHOUT
LIMITATION, AS TO ACCURACY, COMPLETENESS, FITNESS FOR
PURPOSE OR USE, MERCHANTABILITY, NON-INFRINGEMENT,
PERFORMANCE, SAFETY, SUITABILITY AND STABILITY. This SDS is
intended as a guide to the appropriate use, handling, storage and disposal of
the product to which it relates by properly trained personnel, and is not
intended to be comprehensive. Users of Avantor’s products are advised to
perform their own tests and to exercise their own judgment to determine the
safety, suitability and appropriate use, handling, storage and disposal of each
product and product combination for their own purposes and uses. TO THE
GREATEST EXTENT PERMITTED BY LAW, AVANTOR DISCLAIMS
LIABILITY FOR, AND BY USING AVANTOR’S PRODUCTS PURCHASER
AGREES THAT UNDER NO CIRCUMSTANCES SHALL AVANTOR BE
LIABLE FOR, SPECIAL, INDIRECT, INCIDENTAL , PUNITIVE OR
CONSEQUENTIAL DAMAGES OF ANY TYPE OR KIND, INCLUDING
WITHOUT LIMITATION, FOR LOSS OF PROFITS, REPUTATIONAL
DAMAGE, PRODUCT RECALL OR BUSINESS INTERRUPTION.

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