Anaphy Lec Module 5 (Skeletal System - Bones and Joints)
Anaphy Lec Module 5 (Skeletal System - Bones and Joints)
Anaphy Lec Module 5 (Skeletal System - Bones and Joints)
Bone Marrow:
● Red Bone Marrow: Found in the spongy bone of the epiphyses of long bones and in other bones of infants and children. It is responsible for
the production of blood cells.
● Yellow Bone Marrow: Replaces red marrow in adults, primarily composed of fat, though it can revert to red marrow in cases of severe
blood loss.
Bone Ossification:
Bone formation occurs through osteoblasts and results in osteocytes once surrounded by bone matrix.
Types of Bone Formation:
1. Intramembranous Ossification:
○ Occurs in connective tissue, forming flat bones (e.g., skull).
○ Osteoblasts form bone matrix, creating trabeculae and eventually compact bone.
2. Endochondral Ossification:
○ Happens in hyaline cartilage, forming most bones.
○ Chondroblasts form a cartilage model, replaced by bone via osteoblasts.
○ Forms primary (diaphysis) and secondary (epiphysis) ossification centers.
Bone Growth:
1. Elongation:
○ Occurs at the epiphyseal plate, where cartilage is replaced by bone, making bones longer.
○ Growth stops when the plate becomes the epiphyseal line.
2. Appositional Growth:
○ Bone increases in width by deposition on the outer surface and resorption on the inner surface.
Bone Remodeling:
● Osteoclasts resorb old bone, and osteoblasts form new bone.
● Essential for repair, shape changes, and calcium regulation.
● Abnormal remodeling can cause excessive thickening or weak bones (e.g., osteoporosis).
Classification of Bone Fractures:
1. Open Fracture (Compound):
○ Bone breaks through the skin or there is an open wound at the fracture site.
2. Closed Fracture (Simple):
○ Bone fractures without breaking the skin.
3. Complicated Fracture:
○ Soft tissues around a closed fracture are damaged.