Anaphy Lec Module 5 (Skeletal System - Bones and Joints)

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ANAPHY LEC MODULE 5 ( SKELETAL SYSTEM BONES AND JOINTS)

Major Functions of the Skeletal System:


1. Support: Provides structural framework.
2. Protection: Protects vital organs (e.g., skull, rib cage).
3. Movement: Joints facilitate movement with muscle attachment.
4. Mineral Storage: Stores and releases calcium and phosphorus.
5. Blood Cell Formation: Bone marrow produces blood cells.
Extracellular Matrix of Connective Tissues:
● Bone: Contains collagen and minerals (calcium/phosphate).
● Cartilage: Shock absorber, made of collagen and proteoglycans.
● Tendons/Ligaments: Tough, made of collagen; tendons attach muscle to bone, ligaments attach bone to bone.
Bone Types Based on Shape:
1. Long Bones: Longer than wide (e.g., femur, humerus).
○ Diaphysis: Shaft, compact bone.
○ Epiphysis: Ends, spongy bone.
○ Medullary Cavity: Filled with marrow.
2. Short Bones: Equal in width and length (e.g., carpals, tarsals).
3. Flat Bones: Thin and curved, protect organs (e.g., skull, ribs).
4. Irregular Bones: Complex shapes (e.g., vertebrae).
Bone Histology:
● Osteoblasts: Build bone.
● Osteoclasts: Break down bone.
Types of Bone Based on Histology:
1. Compact Bone (Cortical): Dense, forms outer layer; made of osteons.
○ Osteon: Functional unit with osteocytes, lamellae, lacunae, canaliculi, and central canal.
2. Spongy Bone: Lighter, made of trabeculae; found in epiphyses and interior bones.

Bone Marrow:
● Red Bone Marrow: Found in the spongy bone of the epiphyses of long bones and in other bones of infants and children. It is responsible for
the production of blood cells.
● Yellow Bone Marrow: Replaces red marrow in adults, primarily composed of fat, though it can revert to red marrow in cases of severe
blood loss.
Bone Ossification:
Bone formation occurs through osteoblasts and results in osteocytes once surrounded by bone matrix.
Types of Bone Formation:
1. Intramembranous Ossification:
○ Occurs in connective tissue, forming flat bones (e.g., skull).
○ Osteoblasts form bone matrix, creating trabeculae and eventually compact bone.
2. Endochondral Ossification:
○ Happens in hyaline cartilage, forming most bones.
○ Chondroblasts form a cartilage model, replaced by bone via osteoblasts.
○ Forms primary (diaphysis) and secondary (epiphysis) ossification centers.

Bone Growth:
1. Elongation:
○ Occurs at the epiphyseal plate, where cartilage is replaced by bone, making bones longer.
○ Growth stops when the plate becomes the epiphyseal line.
2. Appositional Growth:
○ Bone increases in width by deposition on the outer surface and resorption on the inner surface.

Bone Remodeling:
● Osteoclasts resorb old bone, and osteoblasts form new bone.
● Essential for repair, shape changes, and calcium regulation.
● Abnormal remodeling can cause excessive thickening or weak bones (e.g., osteoporosis).
Classification of Bone Fractures:
1. Open Fracture (Compound):
○ Bone breaks through the skin or there is an open wound at the fracture site.
2. Closed Fracture (Simple):
○ Bone fractures without breaking the skin.
3. Complicated Fracture:
○ Soft tissues around a closed fracture are damaged.

Types of Bone Fractures:


1. Complete: Bone breaks into two or more fragments.
2. Incomplete: Fracture doesn't extend across the bone.
3. Greenstick: Incomplete fracture on the convex side of a bone (common in children).
4. Hairline: Fine, incomplete fracture with no separation of bone fragments (common in skull).
5. Comminuted: Bone breaks into more than two pieces, often with major fragments and smaller ones.
6. Impacted: One bone fragment driven into the spongy portion of the other.
7. Linear: Fracture runs parallel to the length of the bone.
8. Transverse: Fracture runs perpendicular to the length of the bone.
9. Spiral: Fracture takes a helical or spiral course around the bone.
10. Oblique: Fracture runs at an angle to the length of the bone.
11. Dentate: Bone ends are rough and toothed.
12. Stellate: Fracture lines radiate from a central point.
ANAPHY LEC MODULE 5 ( SKELETAL SYSTEM BONES AND JOINTS)

Bone Repair Process:


1. Hematoma Formation:
○ Blood clots form at the fracture site due to bleeding.
2. Callus Formation:
○ A fibrous network forms between the bone fragments.
3. Callus Ossification:
○ Osteoblasts form spongy bone after cartilage model forms, continuing for 4-6 weeks.
4. Bone Remodeling:
○ Spongy bone is remodeled into compact bone over time.
Bone and Calcium (Ca²⁺) Homeostasis:
● Low Blood Calcium:
○ PTH released → stimulates osteoclasts to break down bone → calcium released into blood.
○ PTH also increases calcium reabsorption in kidneys and activates Vitamin D, enhancing calcium absorption from intestines.
● High Blood Calcium:
○ Calcitonin released → inhibits osteoclasts, promotes osteoblasts to deposit calcium into bone.
● Result:
○ Low calcium → increases blood calcium.
○ High calcium → decreases blood calcium.
Anatomical Terms for Bone Features:
● Body / Shaft: Main portion of the bone
● Head: Enlarged, often rounded end of a bone
● Neck: Constricted area between the head and body
● Condyle: Smooth, rounded articular surface
● Facet: Small, flattened articular surface
● Crest: Prominent ridge
● Process: Prominent projection
● Tubercle / Tuberosity: Knob or enlargement
● Trochanter: Large tuberosity found only on the proximal femur
● Epicondyle: Enlargement near or above a condyle
● Foramen: Hole
● Canal / Meatus: Tunnel
● Fissure: Cleft
● Sinus: Cavity
● Fossa: Depression

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