SAFETY DATA SHEET Version 7.

8
Revision Date 01.03.2024
according to Regulation (EC) No. 1907/2006 Print Date 26.04.2024
GENERIC EU MSDS - NO COUNTRY SPECIFIC DATA - NO OEL DATA

SECTION 1: Identification of the substance/mixture and of the company/undertaking

1.1 Product identifiers
Product name : Thionyl chloride
Product Number : 230464
Brand : Sigma-Aldrich
Index-No. : 016-015-00-0
REACH No. : A registration number is not available for this substance as the
substance or its uses are exempted from registration, the
annual tonnage does not require a registration or the
registration is envisaged for a later registration deadline.
CAS-No. : 7719-09-7

1.2 Relevant identified uses of the substance or mixture and uses advised against
Identified uses : Laboratory chemicals, Manufacture of substances
1.3 Details of the supplier of the safety data sheet
Company : Sigma-Aldrich Chemical Pvt Limited
Industrial Area, Anekal Taluka
Plot No 12,
12 Bommasandra - Jigani Link Road
560100 BANGALORE
INDIA

1.4 Emergency telephone

Emergency Phone # : 000 800 1007 141 (CHEMTREC)

SECTION 2: Hazards identification

2.1 Classification of the substance or mixture
Acute toxicity, (Category 4) H302: Harmful if swallowed.

Acute toxicity, (Category 3) H331: Toxic if inhaled.

Skin corrosion, (Sub-category H314: Causes severe skin burns and eye
1A) damage.

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 Serious eye damage, (Category H318: Causes serious eye damage.
1)

Specific target organ toxicity - H335: May cause respiratory irritation.

single exposure, (Category 3),
Respiratory system

2.2 Label elements

Labelling according Regulation (EC) No 1272/2008
Pictogram

Signal Word Danger

Hazard Statements
H302 Harmful if swallowed.
H314 Causes severe skin burns and eye damage.
H331 Toxic if inhaled.
H335 May cause respiratory irritation.
Precautionary Statements
P261 Avoid breathing mist or vapors.
P280 Wear protective gloves/ protective clothing/ eye protection/ face
protection.
P301 + P312 IF SWALLOWED: Call a POISON CENTER/ doctor if you feel
unwell.
P303 + P361 + P353 IF ON SKIN (or hair): Take off immediately all contaminated
clothing. Rinse skin with water.
P304 + P340 + P310 IF INHALED: Remove person to fresh air and keep comfortable
for breathing. Immediately call a POISON CENTER/ doctor.
P305 + P351 + P338 IF IN EYES: Rinse cautiously with water for several minutes.
Remove contact lenses, if present and easy to do. Continue
rinsing.
Supplemental Hazard information (EU)
EUH014 Reacts violently with water.
EUH029 Contact with water liberates toxic gas.

Reduced Labeling (<= 125 ml)

Pictogram

Signal Word Danger

Hazard Statements
H314 Causes severe skin burns and eye damage.
H331 Toxic if inhaled.
Precautionary Statements
P261 Avoid breathing mist or vapors.
P280 Wear protective gloves/ protective clothing/ eye protection/ face
protection.

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 P303 + P361 + P353 IF ON SKIN (or hair): Take off immediately all contaminated
clothing. Rinse skin with water.
P304 + P340 + P310 IF INHALED: Remove person to fresh air and keep comfortable
for breathing. Immediately call a POISON CENTER/ doctor.
P305 + P351 + P338 IF IN EYES: Rinse cautiously with water for several minutes.
Remove contact lenses, if present and easy to do. Continue
rinsing.
Supplemental Hazard information (EU)
EUH014 Reacts violently with water.
EUH029 Contact with water liberates toxic gas.
2.3 Other hazards
This substance/mixture contains no components considered to be either persistent,
bioaccumulative and toxic (PBT), or very persistent and very bioaccumulative (vPvB) at
levels of 0.1% or higher.

Ecological information:
The substance/mixture does not contain components considered to have endocrine
disrupting properties according to REACH Article 57(f) or Commission Delegated regulation
(EU) 2017/2100 or Commission Regulation (EU) 2018/605 at levels of 0.1% or higher.
Toxicological information:
The substance/mixture does not contain components considered to have endocrine
disrupting properties according to REACH Article 57(f) or Commission Delegated regulation
(EU) 2017/2100 or Commission Regulation (EU) 2018/605 at levels of 0.1% or higher.

SECTION 3: Composition/information on ingredients

3.1 Substances
Formula : Cl2OS
Molecular weight : 118,97 g/mol
CAS-No. : 7719-09-7
EC-No. : 231-748-8
Index-No. : 016-015-00-0
Component Classification Concentration
thionyl chloride
CAS-No. 7719-09-7 Acute Tox. 4; Acute Tox. <= 100 %
EC-No. 231-748-8 3; Skin Corr. 1A; Eye
Index-No. 016-015-00-0 Dam. 1; STOT SE 3; H302,
H331, H314, H318, H335
Concentration limits:
>= 1 %: STOT SE 3,
H335;

For the full text of the H-Statements mentioned in this Section, see Section 16.

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SECTION 4: First aid measures
4.1 Description of first-aid measures
General advice
First aiders need to protect themselves. Show this material safety data sheet to the doctor
in attendance.
If inhaled
After inhalation: fresh air. Immediately call in physician. If breathing stops: immediately
apply artificial respiration, if necessary also oxygen.
In case of skin contact
In case of skin contact: Take off immediately all contaminated clothing. Rinse skin with
water/ shower. Call a physician immediately.
In case of eye contact
After eye contact: rinse out with plenty of water. Immediately call in ophthalmologist.
Remove contact lenses.
If swallowed
After swallowing: make victim drink water (two glasses at most), avoid vomiting (risk of
perforation). Call a physician immediately. Do not attempt to neutralise.
4.2 Most important symptoms and effects, both acute and delayed
The most important known symptoms and effects are described in the labelling (see section
2.2) and/or in section 11
4.3 Indication of any immediate medical attention and special treatment needed
No data available

SECTION 5: Firefighting measures

5.1 Extinguishing media
Suitable extinguishing media
Use extinguishing measures that are appropriate to local circumstances and the
surrounding environment.
Unsuitable extinguishing media
Water Foam
5.2 Special hazards arising from the substance or mixture
Sulfur oxides
Hydrogen chloride gas
Not combustible.
May not get in touch with: Water
Ambient fire may liberate hazardous vapours.
5.3 Advice for firefighters
Stay in danger area only with self-contained breathing apparatus. Prevent skin contact by
keeping a safe distance or by wearing suitable protective clothing.
5.4 Further information
Water hydrolyzes material liberating acidic gas which in contact with metal surfaces can
generate flammable and/or explosive hydrogen gas.Suppress (knock down)

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 gases/vapors/mists with a water spray jet. Prevent fire extinguishing water from
contaminating surface water or the ground water system.

SECTION 6: Accidental release measures

6.1 Personal precautions, protective equipment and emergency procedures
Advice for non-emergency personnel: Do not breathe vapors, aerosols. Avoid substance
contact. Ensure adequate ventilation. Evacuate the danger area, observe emergency
procedures, consult an expert.
For personal protection see section 8.
6.2 Environmental precautions
Do not let product enter drains.
6.3 Methods and materials for containment and cleaning up
Cover drains. Collect, bind, and pump off spills. Observe possible material restrictions
(see sections 7 and 10). Take up carefully with liquid-absorbent material (e.g.
Chemizorb®). Dispose of properly. Clean up affected area.
6.4 Reference to other sections
For disposal see section 13.

SECTION 7: Handling and storage

7.1 Precautions for safe handling

Advice on safe handling
Work under hood. Do not inhale substance/mixture. Avoid generation of vapours/aerosols.
Keep workplace dry. Do not allow product to come into contact with water.
Hygiene measures
Immediately change contaminated clothing. Apply preventive skin protection. Wash hands
and face after working with substance.
For precautions see section 2.2.
7.2 Conditions for safe storage, including any incompatibilities
Storage conditions
Tightly closed. Keep in a well-ventilated place. Keep locked up or in an area accessible only
to qualified or authorized persons.
Keep away from water.Never allow product to get in contact with water during storage.

Handle and store under inert gas.

Storage class
Storage class (TRGS 510): 6.1D: Non-combustible, acute toxic Cat.3 / toxic hazardous
materials or hazardous materials causing chronic effects
7.3 Specific end use(s)
Apart from the uses mentioned in section 1.2 no other specific uses are stipulated

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SECTION 8: Exposure controls/personal protection
8.1 Control parameters
Ingredients with workplace control parameters
Derived No Effect Level (DNEL)
Application Area Routes of Health effect Value
exposure
Worker DNEL, inhalation Systemic effects 1 mg/m3
acute
Worker DNEL, inhalation Systemic effects 1 mg/m3
longterm
Remarks This information is not available.
8.2 Exposure controls
Personal protective equipment

Eye/face protection
Use equipment for eye protection tested and approved under appropriate
government standards such as NIOSH (US) or EN 166(EU). Tightly fitting safety
goggles
Skin protection
This recommendation applies only to the product stated in the safety data sheet,
supplied by us and for the designated use. When dissolving in or mixing with other
substances and under conditions deviating from those stated in EN 16523-1 please
contact the supplier of CE-approved gloves (e.g. KCL GmbH, D-36124 Eichenzell,
Internet: www.kcl.de).
Full contact
Material: Viton®
Minimum layer thickness: 0,7 mm
Break through time: 480 min
Material tested:Vitoject® (KCL 890 / Aldrich Z677698, Size M)
This recommendation applies only to the product stated in the safety data sheet,
supplied by us and for the designated use. When dissolving in or mixing with other
substances and under conditions deviating from those stated in EN 16523-1 please
contact the supplier of CE-approved gloves (e.g. KCL GmbH, D-36124 Eichenzell,
Internet: www.kcl.de).
Splash contact
Material: butyl-rubber
Minimum layer thickness: 0,7 mm
Break through time: 120 min
Material tested:Butoject® (KCL 898)
Body Protection
protective clothing
Respiratory protection
Recommended Filter type: Filter type B

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 The entrepeneur has to ensure that maintenance, cleaning and testing of respiratory
protective devices are carried out according to the instructions of the producer.
These measures have to be properly documented.
Control of environmental exposure
Do not let product enter drains.

SECTION 9: Physical and chemical properties

9.1 Information on basic physical and chemical properties
a) Physical state liquid
b) Color No data available
c) Odor No data available
d) Melting Melting point/range: -105 °C - lit.
point/freezing point
e) Initial boiling point 79 °C - lit.
and boiling range
f) Flammability (solid, No data available
gas)
g) Upper/lower No data available
flammability or
explosive limits
h) Flash point Not applicable
i) Autoignition No data available
temperature
j) Decomposition No data available
temperature
k) pH No data available
l) Viscosity Viscosity, kinematic: No data available
Viscosity, dynamic: 0,6 mPa.s at 25 °C
m) Water solubility No data available
n) Partition coefficient: Not applicable for inorganic substances
n-octanol/water
o) Vapor pressure 129 hPa at 20 °C
p) Density 1,631 g/cm3 at 25 °C - lit.
Relative density No data available
q) Relative vapor No data available
density
r) Particle No data available
characteristics

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 s) Explosive properties No data available
t) Oxidizing properties none
9.2 Other safety information
No data available

SECTION 10: Stability and reactivity

10.1 Reactivity
Reacts violently with water.
Contact with water liberates toxic gas.
10.2 Chemical stability
sensitive to moisture
10.3 Possibility of hazardous reactions
Generates dangerous gases or fumes in contact with:
Water
Alcohols
bases
acids
Risk of explosion with:
Ammonia
formaldehyde
sulfoxides
Esters
with
Zinc
Esters
with
Iron
Violent reactions possible with:
sodium
Fluorine

10.4 Conditions to avoid

Do not allow water to enter container because of violent reaction.
Moisture.
10.5 Incompatible materials
Metals
10.6 Hazardous decomposition products
In the event of fire: see section 5

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SECTION 11: Toxicological information
11.1 Information on toxicological effects
Acute toxicity
LD50 Oral - Rat - male - 377 mg/kg
(EC Directive 92/69/EEC B.1 Acute Toxicity (Oral))
LC50 Inhalation - Rat - 4 h - 2,7 mg/l - vapor

(OECD Test Guideline 403)

Dermal: No data available
Skin corrosion/irritation
Remarks: (IUCLID)
Classified according to Regulation (EU) 1272/2008, Annex VI (Table 3.1/3.2)
Remarks: Causes poorly healing wounds.
Serious eye damage/eye irritation
Remarks: Causes serious eye damage.
Respiratory or skin sensitization
No data available
Germ cell mutagenicity
No data available
Carcinogenicity
No data available
Reproductive toxicity
No data available
Specific target organ toxicity - single exposure
May cause respiratory irritation.
Specific target organ toxicity - repeated exposure
No data available
Aspiration hazard
No data available
11.2 Additional Information
Endocrine disrupting properties
Product:
Assessment : The substance/mixture does not contain
components considered to have endocrine
disrupting properties according to REACH Article
57(f) or Commission Delegated regulation (EU)
2017/2100 or Commission Regulation (EU)
2018/605 at levels of 0.1% or higher.
RTECS: XM5150000
Material is extremely destructive to tissue of the mucous membranes and upper respiratory
tract, eyes, and skin.
To the best of our knowledge, the chemical, physical, and toxicological properties have not
been thoroughly investigated.

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SECTION 12: Ecological information
12.1 Toxicity
Toxicity to bacteria Remarks: (IUCLID)
(thionyl chloride)
12.2 Persistence and degradability
No data available
12.3 Bioaccumulative potential
No data available
12.4 Mobility in soil
No data available
12.5 Results of PBT and vPvB assessment
This substance/mixture contains no components considered to be either persistent,
bioaccumulative and toxic (PBT), or very persistent and very bioaccumulative (vPvB) at
levels of 0.1% or higher.
12.6 Endocrine disrupting properties
Product:
Assessment : The substance/mixture does not contain components
considered to have endocrine disrupting properties
according to REACH Article 57(f) or Commission
Delegated regulation (EU) 2017/2100 or Commission
Regulation (EU) 2018/605 at levels of 0.1% or higher.

12.7 Other adverse effects

No data available

SECTION 13: Disposal considerations

13.1 Waste treatment methods
Product
See www.retrologistik.com for processes regarding the return of chemicals and
containers, or contact us there if you have further questions.

SECTION 14: Transport information

14.1 UN number
ADR/RID: 1836 IMDG: 1836 IATA: 1836
14.2 UN proper shipping name
ADR/RID: THIONYL CHLORIDE

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 IMDG: THIONYL CHLORIDE
IATA: Thionyl chloride
Passenger Aircraft: Not permitted for transport
Cargo Aircraft: Not permitted for transport
14.3 Transport hazard class(es)
ADR/RID: 8 IMDG: 8 IATA: 8
14.4 Packaging group
ADR/RID: I IMDG: I IATA: -
14.5 Environmental hazards
ADR/RID: no IMDG Marine pollutant: no IATA: no
14.6 Special precautions for user
Tunnel restriction code : (E)
Further information : No data available

SECTION 15: Regulatory information

15.1 Safety, health and environmental regulations/legislation specific for the
substance or mixture
This material safety data sheet complies with the requirements of Regulation (EC) No.
1907/2006.
National legislation
Seveso III: Directive 2012/18/EU of the H2 ACUTE TOXIC
European Parliament and of the Council
on the control of major-accident hazards
involving dangerous substances.
O1 OTHER HAZARDS

O3 OTHER HAZARDS

Other regulations
Observe work restrictions regarding maternity protection in accordance to Dir 92/85/EEC or
stricter national regulations where applicable.
Take note of Dir 94/33/EC on the protection of young people at work.
15.2 Chemical Safety Assessment
A Chemical Safety Assessment has been carried out for this substance.

SECTION 16: Other information

Full text of H-Statements
H302 Harmful if swallowed.
H314 Causes severe skin burns and eye damage.
H318 Causes serious eye damage.
H331 Toxic if inhaled.
H335 May cause respiratory irritation.

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 EUH014 Reacts violently with water.
EUH029 Contact with water liberates toxic gas.
Full text of other abbreviations
ADN - European Agreement concerning the International Carriage of Dangerous Goods
by Inland Waterways; ADR - Agreement concerning the International Carriage of
Dangerous Goods by Road; AIIC - Australian Inventory of Industrial Chemicals; ASTM -
American Society for the Testing of Materials; bw - Body weight; CMR - Carcinogen,
Mutagen or Reproductive Toxicant; DIN - Standard of the German Institute for
Standardisation; DSL - Domestic Substances List (Canada); ECx - Concentration
associated with x% response; ELx - Loading rate associated with x% response; EmS -
Emergency Schedule; ENCS - Existing and New Chemical Substances (Japan); ErCx -
Concentration associated with x% growth rate response; GHS - Globally Harmonized
System; GLP - Good Laboratory Practice; IARC - International Agency for Research on
Cancer; IATA - International Air Transport Association; IBC - International Code for the
Construction and Equipment of Ships carrying Dangerous Chemicals in Bulk; IC50 - Half
maximal inhibitory concentration; ICAO - International Civil Aviation Organization;
IECSC - Inventory of Existing Chemical Substances in China; IMDG - International
Maritime Dangerous Goods; IMO - International Maritime Organization; ISHL - Industrial
Safety and Health Law (Japan); ISO - International Organisation for Standardization;
KECI - Korea Existing Chemicals Inventory; LC50 - Lethal Concentration to 50 % of a
test population; LD50 - Lethal Dose to 50% of a test population (Median Lethal Dose);
MARPOL - International Convention for the Prevention of Pollution from Ships; n.o.s. -
Not Otherwise Specified; NO(A)EC - No Observed (Adverse) Effect Concentration;
NO(A)EL - No Observed (Adverse) Effect Level; NOELR - No Observable Effect Loading
Rate; NZIoC - New Zealand Inventory of Chemicals; OECD - Organization for Economic
Co-operation and Development; OPPTS - Office of Chemical Safety and Pollution
Prevention; PBT - Persistent, Bioaccumulative and Toxic substance; PICCS - Philippines
Inventory of Chemicals and Chemical Substances; (Q)SAR - (Quantitative) Structure
Activity Relationship; REACH - Regulation (EC) No 1907/2006 of the European
Parliament and of the Council concerning the Registration, Evaluation, Authorisation and
Restriction of Chemicals; RID - Regulations concerning the International Carriage of
Dangerous Goods by Rail; SADT - Self-Accelerating Decomposition Temperature; SDS -
Safety Data Sheet; TCSI - Taiwan Chemical Substance Inventory; TECI - Thailand
Existing Chemicals Inventory; TSCA - Toxic Substances Control Act (United States); UN
- United Nations; UNRTDG - United Nations Recommendations on the Transport of
Dangerous Goods; vPvB - Very Persistent and Very Bioaccumulative

Further information
The information is believed to be correct but is not exhaustive and will be used solely as
a guideline, which is based on current knowledge of the chemical substance or mixture
and is applicable to appropriate safety precautions for the product. It does not represent
any guarantee of the properties of the product. Sigma-Aldrich Corporation and its
Affiliates shall not be held liable for any damage resulting from handling or from contact
with the above product. See www.sigma-aldrich.com and/or the reverse side of invoice
or packing slip for additional terms and conditions of sale.
Copyright 2020 Sigma-Aldrich Co. LLC. License granted to make unlimited paper copies
for internal use only.
The branding on the header and/or footer of this document may temporarily not visually match
the product purchased as we transition our branding. However, all of the information in the

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document regarding the product remains unchanged and matches the product ordered. For
further information please contact mlsbranding@sial.com.

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