disobedience }

I don't care if she commits atrocities, bro, she's justified by the narrative

Endwalker Week - Varshahn/Vrtra

I AM PARACHUTING IN, FOR YOUR THIRTY TWO HUNDRED DOLLAS

grrrrr....

This one really does just gain momentum with every new word, huh?

hey I'm sorry I stopped in the middle of that sentence my brain decided to flush its cache and I totally forgot what this conversation was

Something I found on Twitter that really puts things in perspective as a creator.

i cant stop saying "grisp it"

developing your ocs is 50% waiting for bursts of divine inspiration like an oracle sleeping next the vapours seeping from fissures in the temple floor and 50% stalking them in your mind relentlessly like a persistence predator until they tire out enough for you to get close and scamper away with the bloody scraps of "eye colour: brown" and "dislikes: people who think they're funny" clutched in your mouth like a hunting trophy

"Two researchers in the US and Australia have discovered important mechanisms that prevent B cells from attacking the body’s own tissues in autoimmune diseases like arthritis, lupus, and multiple sclerosis—and in the process have won a prestigious prize.

Normally, the body’s immune system protects us from viruses, bacteria, and foreign substances. However, in autoimmune diseases, the immune system starts attacking tissues in the body instead.

Researchers had long tried to discover the cause of autoimmune diseases. But, Christopher Goodnow and David Nemazee, independently of each other, adopted a new approach.

They asked why we do not all develop these diseases. Their focus was on B cells which, together with white blood cells and T cells, are the building blocks of our complex immune system.

“They have given us a new and detailed understanding of the mechanisms that normally prevent faulty B cells from attacking tissues in the body, explaining why most of us are not affected by autoimmune diseases,” says Olle Kämpe, member of the Royal Swedish Academy of Sciences and chair of the Crafoord Prize committee that awarded the pair 6 million Swedish kronor ($600,000).

Neutralize B cells

In recent years, physicians have started to experiment by using existing drugs to neutralize B cells for patients with severe autoimmune diseases, including lupus, rheumatoid arthritis, and multiple sclerosis, which has proven to be very effective at improving their quality of life.

Thanks to this year’s Crafoord Prize Laureates, we have gained fundamental new knowledge about what is happening in the immune system during autoimmune disease attacks.

“This also paves the way for development of new forms of therapies that eventually can cure these diseases—or might prevent them in the future,” said one professor of clinical immunology at the Royal Swedish Academy of Sciences...

More details from the video, since the article glosses over the particulars:

"The laureates discovered what is now called B cell tolerance.

When B cells develop in the bone marrow, not all of them are perfect. To remove the faulty ones, a mechanism starts, in which defective cells are programmed to destroy themself through apoptosis.

The laureates discovered two new mechanisms that are used if some of the bad cells are left. Re-editing, where the immune system alters the combination of receptors, and anergy, that silences B cells with self-reactive receptors.

The laureates were able to demonstrate that these mechanisms sometimes fail. This means that faulty B cells can cause an attack on the body's own tissues – leading to autoimmune diseases.

Thanks to the laureate’s discoveries, doctors like Anders Bengtsson soon felt able to start treating patients with lupus, arthritis, multiple sclerosis, and many other autoimmune diseases, with medicines that eradicated B cells.

Anders Bengtsson: "I'm very happy that B cells has gotten so much attention because of the laureates. I have seen my patients getting so much better and getting a better life."

Autoimmune patient: "Today, I feel very good. I really have hope in the research that it will revolutionise things and perhaps even cure it all. That’s what I want, hope for, and believe in.""

-Article via Good News Network, April 6, 2025. Video via The Royal Swedish Academy of Sciences, January 29, 2025.

My favourite thing in the world is seeing folks act like real human beings around big celebrity personalities

I’d like to live through a week that’s not a whole new verse of “We Didn’t Start the Fire.”

#dated three four years ago is really what makes this one#sorry op if you still have notifications on for this one#but hoo-wee did you hit on the sentiment of the decade

I do have notifications still on for this post because I love the sense of community it gives me. We're all just staring at each other blankly and occasionally screaming.

Also for the people who have post dates turned on and just go JESUS CHRIST FOUR YEARS AGO?!

Sabrina the Teenage Witch – 3.04: The Pom Pom Incident

it is absolutely essential to have friends you can have extremely insane pervert conversations with. this is kind of what makes life worth living

i wish there was an easier way to tell the difference between an "if it sucks hit da bricks" situation and a "sometimes being an adult means doing things that you dont wanna" situation

The best answer to this that I've seen is "You are free to do whatever you like. You must only live with the consequences."

"If it sucks, hit da bricks" is for when you realize that you actually definitely can live with the consequences of Not Doing The Thing.

"Sometimes being an adult means doing things that you don't wanna" is for when you've thought it over and it turns out you would strongly prefer NOT to live with the consequences of Not Doing The Thing.

big fan of 'i'd find you in every universe'. BIGGER fan of 'there are maybe five universes where we find each other and in four of them it ends badly i think we're some kind of anomaly i think every law of everything points towards this being the death of us. but we could try to save it anyway.' THATS the good shit.