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Cachectin and tumour necrosis factor as two sides of the same biological coin

Nature volume 320, pages 584–588 (1986)Cite this article

Abstract

In response to invasive stimuli, macrophages secrete cachectin, a multipotent protein. Prominent among its biological effects is the ability to induce wasting (cachexia) as well as a lethal state of shock. The identity of cachectin and tumour necrosis factor has led to a new view of its therapeutic potential.

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Authors and Affiliations

  1. Laboratory of Medical Biochemistry, The Rockefeller University, New York, New York, 10021, USA

    Bruce Beutler & Anthony Cerami

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  1. Bruce Beutler
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Beutler, B., Cerami, A. Cachectin and tumour necrosis factor as two sides of the same biological coin. Nature 320, 584–588 (1986). https://doi.org/10.1038/320584a0

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