SB-399885

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SB-399885
SB399885.png
Systematic (IUPAC) name
N-(3,5-Dichloro-2-methoxyphenyl)-4-methoxy-3-(1-piperazinyl)benzenesulfonamide
Identifiers
CAS Number 402713-80-8 YesY
PubChem CID: 6918649
IUPHAR/BPS 3241
ChEMBL CHEMBL1210710 N
Chemical data
Formula C18H21Cl2N3O4S
Molecular mass 446.347 g/mol
  • C3CNCCN3c2cc(ccc2OC)S(=O)(=O)Nc(c1OC)cc(Cl)cc1Cl
 NYesY (what is this?)  (verify)

SB-399885 is a drug which is used in scientific research. It acts as a potent, selective and orally active 5-HT6 receptor antagonist, with a Ki of 9.0nM. SB-399885 and other 5-HT6 antagonists show nootropic effects in animal studies,[1][2] as well as antidepressant and anxiolytic effects which are comparable to and synergistic with drugs such as imipramine and diazepam,[3][4][5] and have been proposed as potential novel treatments for cognitive disorders such as schizophrenia[6] and Alzheimer's disease.

References

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