Elfazepam

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Elfazepam
Elfazepam.svg
Systematic (IUPAC) name
7-Chloro-1-(2-ethylsulfonylethyl)-5-(2-fluorophenyl)-3H-1,4-benzodiazepin-2-one
Identifiers
CAS Number 52042-01-0 YesY
ATC code none
PubChem CID: 65445
ChemSpider 58907 YesY
UNII RM53R5R2BL YesY
Chemical data
Formula C19H18ClFN2O3S
Molecular mass 408.87
  • O=S(CC)(CCN1C(CN=C(C2=CC=CC=C2F)C3=C1C=CC(Cl)=C3)=O)=O
  • InChI=1S/C19H18ClFN2O3S/c1-2-27(25,26)10-9-23-17-8-7-13(20)11-15(17)19(22-12-18(23)24)14-5-3-4-6-16(14)21/h3-8,11H,2,9-10,12H2,1H3 YesY
  • Key:BSPSXMXQKZZNFP-UHFFFAOYSA-N YesY
  (verify)

Elfazepam[1] is a drug which is a benzodiazepine derivative.[2] Presumably it has sedative and anxiolytic actions like those of other benzodiazepines.

It has appetite stimulating properties in animals.[3][4] The mechanism for increasing feed intake is not clear and has been subject of investigation.[5] It has been found that elfazepam suppresses gastric acid secretion.[6]

Synthesis

Elfazepam synthesis: U.S. Patent 4,010,154

Benzophenone derivative 1 is reacted with a glycine equvalent masked as an oxazolidine-2,5-dione.

References

  1. ↑ U.S. Patent 4,010,154
  2. ↑ Psychotropics.dk
  3. ↑ Lua error in package.lua at line 80: module 'strict' not found.
  4. ↑ Lua error in package.lua at line 80: module 'strict' not found.
  5. ↑ Lua error in package.lua at line 80: module 'strict' not found.
  6. ↑ Lua error in package.lua at line 80: module 'strict' not found.

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