Flutemazepam

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Flutemazepam
Flutemazepam structure.svg
Systematic (IUPAC) name
7-chloro-5-(2-fluorophenyl)-3-hydroxy-1-methyl-3H-1,4-benzodiazepin-2-one
Clinical data
Pregnancy
category
  • X
Legal status
Routes of
administration		 Oral
Identifiers
CAS Number 52391-89-6 N
ATC code none
PubChem CID: 40344
ChemSpider 36859 YesY
UNII J8U5694BCW YesY
ChEMBL CHEMBL291770 YesY
Chemical data
Formula C16H12ClFN2O2
Molecular mass 318.730
  • FC1=CC=CC=C1C2=NC(C(N(C)C3=C2C=C(C=C3)Cl)=O)O
  • InChI=1S/C16H12ClFN2O2/c1-20-13-7-6-9(17)8-11(13)14(19-15(21)16(20)22)10-4-2-3-5-12(10)18/h2-8,15,21H,1H3 YesY
  • Key:RMFYWNFETXNTIQ-UHFFFAOYSA-N YesY
 NYesY (what is this?)  (verify)

Flutemazepam[1] was developed at a team at Stabilimenti Chimici Farmaceutici Riuniti SpA in the mid 1970s. Is a drug which is a 3-hydroxy benzodiazepine derivative and an analogue of temazepam that has hypnotic, sedative, amnesiac, anxiolytic, anticonvulsant and skeletal muscle relaxant properties. It is most closely related in structure to temazepam and is indicated for the treatment of severe insomnia.[2] Flutemazepam has properties similar to temazepam, and it has been found to be very effective for the treatment of severe states of anxiety, panic attacks, and severe insomnia.[3]

See also

References

  1. ↑ GB Patent 1431282 - BENZODIAZEPINE COMPOUNDS FOR THEREPEUTICAL USE
  2. ↑ Lua error in package.lua at line 80: module 'strict' not found.
  3. ↑ Ian K.M. Morton, Judith M. Hall. Concise Dictionary of Pharmacological agents. Springer, 1999. ISBN 0-7514-0499-3, ISBN 978-0-7514-0499-9

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