NS-2664

NS-2664

Systematic (IUPAC) name
5-furan-3-yl-1-(3-imidazol-1-yl-phenyl)-1H-benzoimidazole
Identifiers
PubChem	CID: 9840300
ChemSpider	8016018 N
Chemical data
Formula	C20H14N4O
Molecular mass	326.351 g/mol
SMILES c5occc5-c(cc1nc4)ccc1n4-c2cc(ccc2)-n3cncc3
InChI InChI=1S/C20H14N4O/c1-2-17(23-8-7-21-13-23)11-18(3-1)24-14-22-19-10-15(4-5-20(19)24)16-6-9-25-12-16/h1-14H N Key:QMKRPSVBKKEAKS-UHFFFAOYSA-N N
NY (what is this?)  (verify)

NS-2664 (LS-193,048) is an anxiolytic drug with a novel chemical structure, developed by the small pharmaceutical company Neurosearch. It has similar effects to benzodiazepine drugs, but is structurally distinct and so is classed as a nonbenzodiazepine anxiolytic. NS-2664 is a potent but non-selective partial agonist at GABA_A receptors, although with little efficacy at the α1 subtype and more at α2 and α3. It has potent anticonvulsant effects in animal studies, but a relatively short duration of action, and produces little sedative effects or physical dependence.