Pyrazolam

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Pyrazolam structure.svg
Systematic (IUPAC) name
8-Bromo-1-methyl-6-(pyridin-2-yl)-4H-[1,2,4]triazolo[4,3-a][1,4]benzodiazepine
Clinical data
Legal status
Routes of
administration		 Oral, Sublingual, rectal
Pharmacokinetic data
Biological half-life 17 hours
Identifiers
CAS Number 39243-02-2
PubChem CID: 12562545
ChemSpider 15417688
UNII 8LH16383PK YesY
Chemical data
Formula C16H12BrN5
Molecular mass 354.204 g/mol
  • CC1=NN=C2CN=C(C3=NC=CC=C3)C3=CC(Br)=CC=C3N12
  • InChI=1S/C16H12BrN5/c1-10-20-21-15-9-19-16(13-4-2-3-7-18-13)12-8-11(17)5-6-14(12)22(10)15/h2-8H,9H2,1H3
  • Key:BGRWSFIQQPVEML-UHFFFAOYSA-N

Pyrazolam is a benzodiazepine derivative originally developed by a team led by Leo Sternbach at Hoffman-La Roche in the 1970s,[1] and subsequently "rediscovered" and sold as a designer drug and research chemical starting in 2012.[2]

Pyrazolam has structural similarities to alprazolam[3] and bromazepam. Unlike other benzodiazepines, pyrazolam does not appear to undergo metabolism, instead being excreted unchanged in the urine.[2][4] It is most selective for the α2 and α3 subtypes of the GABAA receptor.[5]

References

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  1. ↑ US 3954728, "Preparation of triazolo benzodiazepines and novel compounds" 
  2. ↑ 2.0 2.1 Lua error in package.lua at line 80: module 'strict' not found.
  3. ↑ Lua error in package.lua at line 80: module 'strict' not found.
  4. ↑ Characterization of the designer benzodiazepines pyrazolam and flubromazepam and study on their detectability in human serum and urine samples, B. Moosmann, M. Hutter, L. M. Huppertz and V. Auwärter
  5. ↑ Lua error in package.lua at line 80: module 'strict' not found.
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