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Immunological disorders are diseases or conditions caused by a dysfunction of the immune system and include allergy, asthma, autoimmune diseases, autoinflammatory syndromes and immunological deficiency syndromes.
On 11–12 September 2024, the National Institute of Allergy and Infectious Diseases (NIAID) convened experts to discuss associations between microorganisms and the development of autoimmune diseases.
IL-36 receptor is crucial for host defense and tissue repair. Here, the authors describe identification and characterization of low molecular weight inhibitors of the IL-36 receptor using encoded library technologies. This represents a rare example of small molecules inhibiting a member of IL-1 receptor family.
Gain-of-function variants in the gene encoding NLRP3 lead to constitutive inflammasome activation and excessive IL-1β production. In this resource, authors perform functional screening of clinically relevant NLRP3 variants. Structural analysis suggested multiple mechanisms by which variants activate NLRP3 and the identification of pathogenic variants that can sensitize the activation of NLRP3 in response to nigericin and cold temperature exposure.
On 11–12 September 2024, the National Institute of Allergy and Infectious Diseases (NIAID) convened experts to discuss associations between microorganisms and the development of autoimmune diseases.
Systemic lupus erythematosus (SLE) is an autoimmune disease with considerable clinical heterogeneity and diverse treatment options. A study now shows that heightened extrafollicular B cells and anti-BAFF therapy are linked to inferior responses to COVID-19 vaccines.
Synovial dendritic cell profiles and localization patterns provide insights about the roles of dendritic cell subsets in the initiation, remission and relapse of rheumatoid arthritis.
