Scribd Logo
Upload

Welcome to Scribd!

  • 60 views

    Immuno Bull Ous Skin DZ

    Uploaded by

    Ismail Bin Rahmat
    This document provides an algorithm for testing for immunobullous skin diseases. It outlines the indications for testing, recommended tests, and follow up based on test results. The algorithm is complex and considers many factors like disease type, symptoms, pregnancy status, and test results.

    Copyright:

    © All Rights Reserved
    Download as PDF, TXT or read online from Scribd

    Immuno Bull Ous Skin DZ

    Uploaded by

    Ismail Bin Rahmat
    60 views1 page
    This document provides an algorithm for testing for immunobullous skin diseases. It outlines the indications for testing, recommended tests, and follow up based on test results. The algorithm is complex and considers many factors like disease type, symptoms, pregnancy status, and test results.

    Original Description:

    Table penyakit bulosa

    Original Title

    Immuno Bull Ous Skin Dz

    Copyright

    © © All Rights Reserved

    Available Formats

    PDF, TXT or read online from Scribd

    Did you find this document useful?

    Is this content inappropriate?

    This document provides an algorithm for testing for immunobullous skin diseases. It outlines the indications for testing, recommended tests, and follow up based on test results. The algorithm is complex and considers many factors like disease type, symptoms, pregnancy status, and test results.

    Copyright:

    © All Rights Reserved
    Download as PDF, TXT or read online from Scribd
    Download as pdf or txt
    60 views1 page

    Immuno Bull Ous Skin DZ

    Uploaded by

    Ismail Bin Rahmat
    This document provides an algorithm for testing for immunobullous skin diseases. It outlines the indications for testing, recommended tests, and follow up based on test results. The algorithm is complex and considers many factors like disease type, symptoms, pregnancy status, and test results.

    Copyright:

    © All Rights Reserved
    Download as PDF, TXT or read online from Scribd
    Download as pdf or txt
    You are on page 1of 1

    Immunobullous Skin Diseases Testing Click here for topics associated with this algorithm

    INDICATIONS FOR TESTING


    Symptomatic adults

    Screen for Immunobullous Diseases (pemphigus, pemphigoid, epidermolysis Pregnant female, typically 2nd trimester
    Presence of neoplastic disease
    bullosa acquisita, linear IgA disease, or dermatitis herpetiformis)
    Perilesional skin biopsy Perilesional skin biopsy for Cutaneous Direct Perilesional skin biopsy for Cutaneous Direct
    Cutaneous Direct Immunofluorescence, Biopsy 0092572 Immunofluorescence, Biopsy 0092572 Immunofluorescence, Biopsy 0092572
    Serum tests AND AND
    Pemphigus Panel 0090650, Pemphigoid Panel 0092001, and Endomysial Paraneoplastic Pemphigus Antibody Screen 0092107 Herpes Gestationis Factor 0092283
    Antibodies 0050734 (all 3 tests recommended unless specific disease type
    strongly suspected) positive negative negative positive
    OR
    Epithelial Skin Antibodies 0090299 and Endomysial Antibodies 0050734
    Screen for Screen for Herpes Gestationis
    Paraneoplastic
    Immunobullous Immunobullous Will resolve post pregnancy
    positive, titer >1:10 Pemphigus Likely to occur with subsequent pregnancies
    diseases diseases
    May occur with other hormonal changes, including
    negative
    contraception

    Monitor for developing


    immunobullous disease
    IgA endomysial
    Repeat screening: antibodies* IgG basement
    In 3-6 months for persistent IgA basement membrane IgG cell surface IgA cell surface
    membrane zone
    unexplained disease zone epidermal, dermal
    In 6-12 weeks for rapidly or combined epidermal/
    evolving disease dermal pattern Pemphigus
    Order Pemphigus IgA
    Skin biopsy for granular Antibodies 0092106 as
    or fibrillar IgA Epidermal Combined Dermal IgG Desmoglein-1 and additional or separate test
    pattern epidermal/dermal pattern Desmoglein-3 0090649 for suspected IgA
    negative positive Linear IgA disease
    (Note: Necessary if pemphigus
    pemphigoid panel testing
    Epidermolysis was not ordered) negative positive
    Monitor treatment Pemphigoid bullosa acquisita
    positive
    response Desmoglein-1 Desmoglein-3
    Repeat Dermatitis Epithelial Basement Monitor treatment positive positive
    skin biopsy herpetiformis Membrane Zone IgA Bullous Pemphigoid response
    Antibodies 0092057 Antigens IgG Epithelial Basement IgA
    P. foliaceus P. vulgaris
    OR BP180 and BP230 Membrane Zone IgG Pemphigus
    (most common) (most common)
    Epithelial Skin 0092566 Antibodies 0092056 OR OR
    Antibody 0090299 (Note: Necessary if OR P. erythematosus P. vegetans
    pemphigoid panel Epithelial Skin
    Monitor treatment testing was not Antibody 0090299
    response ordered)
    IgA endomysial* Monitor treatment
    and Tissue Monitor treatment response
    Transglutaminase response Pemphigus IgA
    Antibodies IgA, IgG Monitor treatment response Pemphigus Panel Antibodies 0092106
    0097709, 0056009 Pemphigoid Panel 0092001 0090650

    * For Endomysial Antibodies, a screening IgA tissue transglutaminase assay (ELISA) can be ordered OR request Endomysial Antibody test by indirect immunofluorescence (IgA and/or IgG) with or without accompanying
    IgA and/or IgG tissue transglutaminase assay through the Immunodermatology Laboratory.

    © 2006-2008 ARUP Laboratories. All Rights Reserved. Revised 9/2/08 www.arupconsult.com

    You might also like