St. Paul University Philippines: /almarallag/v01/2020-21

St.
Paul University Philippines

Tuguegarao City 3500 Cagayan
School of Nursing and Allied Health Sciences

College of Nursing
DRUG STUDY
Generic Name of Drug: (1

point)
Meperidine
Drug Classification: (1
point)
Opioid Analgesics, Synthetic, Opioids
Drug Action/s: (1
point)
Meperidine is primarily a kappa-opiate receptor agonist and also has local anesthetic effects.
Meperidine has more affinity for the kappa-receptor than morphine. Opiate receptors are
coupled with G-protein receptors and function as both positive and negative regulators of
synaptic transmission via G-proteins that activate effector proteins. Binding of the opiate
stimulates the exchange of GTP for GDP on the G-protein complex. As the effector system is
adenylate cyclase and cAMP located at the inner surface of the plasma membrane, opioids
decrease intracellular cAMP by inhibiting adenylate cyclase. Subsequently, the release of
nociceptive neurotransmitters such as substance P, GABA, dopamine, acetylcholine and
noradrenaline is inhibited. Opioids also inhibit the release of vasopressin, somatostatin,
insulin and glucagon. Opioids close N-type voltage-operated calcium channels (OP2-receptor
agonist) and open calcium-dependent inwardly rectifying potassium channels (OP3 and OP1
receptor agonist). This results in hyperpolarization and reduced neuronal excitability.
Dose, frequency and route of administration (doctor’s order): (1
point)
50mg, PRN, IV Injection
Indication/s (reason/s) for administering the medication to the patient: (1

point)
Meperidine injection is used to relieve moderate to severe pain. It may be used before or
during surgery, or to relieve pain during labor or delivery.
Two (2) most common side-effects of the Two (2) most common adverse effects of
medication (2 points) the medication (2 points)
- Dizziness or feeling sleepy - Vomiting
- Sweating or nausea - Lightheadedness
List two (2) important nursing responsibilities you have to consider when administering the
medication: (2
points)
- Assess BP, pulse and respiratory rate prior to administration and frequently during
administration
- Follow strictly the doctor’s order
List three (3) patient health teachings in relation to the medication: (3

points)
- Take drug exactly as prescribed
- Do not take leftover medication or any over-the-counter drugs,
/almarallag/v01/2020-21
- Report severe nausea, vomiting, constipation, shortness of breath, or difficulty
breathing
Generic Name of Drug: (1

point)
Promethazine
Drug Classification: (1
point)
Antiemetic Agents
Drug Action/s:
Promethazine is a an antagonist of histamine H1, post-synaptic mesolimbic dopamine, alpha
adrenergic, muscarinic, and NMDA receptors. The antihistamine action is used to treat
allergic reactions. Antagonism of muscarinic and NMDA receptors contribute to its use as a
sleep aid, as well as for anxiety and tension. Antagonism of histamine H1, muscarinic, and
dopamine receptors in the medullary vomiting center make promethazine useful in the
treatment of nausea and vomiting.
(1 point)
Dose, frequency and route of administration (doctor’s order): (1

point)
25mg, PRN, IV Injection
Indication/s (reason/s) for administering the medication to the patient: (1

point)
Promethazine is used to prevent and treat nausea and vomiting related to certain conditions
(such as before/after surgery, motion sickness). It is also used with other medication to treat
severe allergic reactions (anaphylaxis) and reactions to blood products. It may also be used to
treat milder allergic reactions when you cannot take promethazine by mouth. It may also be
used to help you feel sleepy/relaxed before and after surgery, during other procedures, or
during labor and delivery.
Two (2) most common side-effects of the Two (2) most common adverse effects of
medication (2 points) the medication (2 points)
- Dizziness - Constipation
- Tired feeling - Blurred vision
List two (2) important nursing responsibilities you have to consider when administering the
medication: (2
points)
- Promethazine may be used alone or as an adjunct to narcotic analgesics during labor
and delivery
- Assess vital signs before administering
List three (3) patient health teachings in relation to the medication: (3

points)
- Take drug exactly as prescribed
- Maintain fluid intake
- Report sore throat, fever, unusual bleeding or bruising, rash, weakness, tremors,
impaired vision, dark urine, pale stools, yellowing of the skin or eyes.
References: (follow APA format) (1 point)
Score: ___ /20
Evaluated by:
________________________________
Name and Signature of Class Facilitator
Date evaluated: _________________________

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St.

Paul University Philippines

School of Nursing and Allied Health Sciences

Generic Name of Drug: (1

Indication/s (reason/s) for administering the medication to the patient: (1

List three (3) patient health teachings in relation to the medication: (3

Generic Name of Drug: (1

Dose, frequency and route of administration (doctor’s order): (1

Indication/s (reason/s) for administering the medication to the patient: (1

List three (3) patient health teachings in relation to the medication: (3

Score: ___ /20

Date evaluated: _________________________

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