Meningitis in Children

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Meningitis in Children

SGD 16
Definition and Etiology
• Def: Inflammation of the meninx • Meningitis could be caused by
or meninges the infectious or the non-
infectious processes

• Infectious process could be


caused by bacteria, viruses, or
fungi. Parasites less commonly
cause it

• Non-infectious process is usually


caused by cancer, autoimmunity,
or drug reactions
Risk Factors
• Chronic medical conditions • Bacterial endocarditis
(renal failure, diabetes, adrenal • Ventriculoperitoneal shunt
insufficiency, or cystic fibrosis)
• Malignancy
• Undervaccination
• IV drug use
• Extremes of age
• Immunosuppressed states (AIDS,
iatrogenic, congenital
immunodeficiency, or transplant
recipients)
• Sickle cell anemia
• Splenectomy
Pathophysiology of Pediatric
Meningitis
Signs and Symptoms
More Signs and Symptoms
How to Diagnose It

Preface Anamnesis Findings


• Anamnesis, vital and physical • Headache
examinations, and evaluating • Fever
tests are required to diagnose
a disease well • Nuchal rigidity
• In the pediatric case, signs • History of vaccination (-)
and symptoms of meningitis • Photophobia & phonophobia
are less evident, especially in • Nausea/vomiting
neonates and infants
More Information

Vital & Physical Examinations Laboratory Tests


• Loss or decreased consciousness (mostly • CSF analysis
normal)
• CT scans/MRI ( to eliminate the differential
• Hyperthermia (sometimes could be diagnoses)
hypothermia or normothermia)
• PCR (for viral meningitis)
• Petechia/ae or purpura could be found
• Respiratory problems • Findings will be explained later
• Nuchal rigidity (positive Brudzinski’s and
Kernig’s signs)
• Seizure
• Ataxia Ataxia →
• Focal neurological deficits
Meningeal Examinations & Laboratory
Findings
Brudzinski’s and Kernig’s Tests CSF Analysis
Differential Diagnoses
• Encephalitis
• Meningoencephalitis
• Lupus
Management of Meningitis

Management Bacterial Meningitis


• Management could be
decided based on its etiology
Bacterial Meningitis & Viral Meningitis
Managements
Bacterial Meningitis Viral Meningitis
Management of Meningitis

Viral Meningitis Tuberculous Meningitis


• Viral meningitis could go easier than the • Isoniazid 10-20 mg/KgBW/day (c), 400 mg/day (a)
bacterial one • Rifampicin 10-20 mg/KgBW/day (c), 600 mg/day
• Ethambutol 25 mg/KgBW/day, 150 mg/day

• Antipyretics and pain relievers could • Streptomycin IM for 3 months 30-50 mg/KgBW/day
alleviate the symptoms • Para-aminosalicylic acid 200 mg/KgBW/day divided
into 3 doses, could be administered up to 12 g/day
• Corticosteroids: Prednisone 2-3mg/KgBW/day, 20
• Bed rest is also needed mg/day divided into 3 doses for 2-4 weeks followed
by 1-2 mg/KgBW/day for 1-2 months.
Dexamethasone (IV) could be administered if the
cerebral edema is present, 10 mg every 4-6 hours, if
it is improving, physicians could lower it to 4 mg of
Dexamethasone, given every 6 hours
Status Epilepticus Management

Pediatric Adult
Prognosis and Complications

Prognosis Complications
• Around 25% of the cases could cause • Increased intracranial pressure: cerebral
mortality edema
• 50-80% possibility to cause mortality in • Hydrocephalus
untreated patients
• Focal neurological deficits
• 10-20% patients have the remaining • Cerebrovascular complications
symptoms

• Ad vitam → Dubia ad bonam/Dubia


(fungal)
• Ad sanationam → Dubia ad bonam/Dubia
(fungal)
• Ad functionam → Dubia ad bonam/Dubia
ad malam (viral)/Dubia (fungal)
Education and Prevention

Education Prevention
• Give the people the socialization • Vaccination (complete)
about meningitis • Washing hands
• Let people know that meningitis • Good sanitation
is contagious, could be spread
through droplets, kissing, open • See a doctor immediately to
wound, food, etc prevent further complications
• Teach the importance of
washing hands with soap and
water
• Tell patients to take their
medications routinely

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