My bind of @facewithoutheart's fic This Will All Go Down In Flames

I know most people don't care about anything unless it has to do with the U.S. but can we please start talking about the Canadian election.

Please don't vote for Poilievre. He's basically the Canadian Trump and plans to put in place laws that harm trans youth, and lots of other shit.

Please vote istg this is the only way anything will get better. Poilievre has been kissing millionaires and billionaires asses. He'll make life even harder, and he loves Trump.

Reblogs are appreciated, especially if you aren't Canadian.

I am Canadian, and the OP is absolutely correct. Non-Canadian mutuals, feel free to reblog. Thanks.

If you see this you’re legally obligated to reblog and tag with the book you’re currently reading

common spiny flower mantis, as an apology for the hiatus🌷

"Two researchers in the US and Australia have discovered important mechanisms that prevent B cells from attacking the body’s own tissues in autoimmune diseases like arthritis, lupus, and multiple sclerosis—and in the process have won a prestigious prize.

Normally, the body’s immune system protects us from viruses, bacteria, and foreign substances. However, in autoimmune diseases, the immune system starts attacking tissues in the body instead.

Researchers had long tried to discover the cause of autoimmune diseases. But, Christopher Goodnow and David Nemazee, independently of each other, adopted a new approach.

They asked why we do not all develop these diseases. Their focus was on B cells which, together with white blood cells and T cells, are the building blocks of our complex immune system.

“They have given us a new and detailed understanding of the mechanisms that normally prevent faulty B cells from attacking tissues in the body, explaining why most of us are not affected by autoimmune diseases,” says Olle Kämpe, member of the Royal Swedish Academy of Sciences and chair of the Crafoord Prize committee that awarded the pair 6 million Swedish kronor ($600,000).

Neutralize B cells

In recent years, physicians have started to experiment by using existing drugs to neutralize B cells for patients with severe autoimmune diseases, including lupus, rheumatoid arthritis, and multiple sclerosis, which has proven to be very effective at improving their quality of life.

Thanks to this year’s Crafoord Prize Laureates, we have gained fundamental new knowledge about what is happening in the immune system during autoimmune disease attacks.

“This also paves the way for development of new forms of therapies that eventually can cure these diseases—or might prevent them in the future,” said one professor of clinical immunology at the Royal Swedish Academy of Sciences...

More details from the video, since the article glosses over the particulars:

"The laureates discovered what is now called B cell tolerance.

When B cells develop in the bone marrow, not all of them are perfect. To remove the faulty ones, a mechanism starts, in which defective cells are programmed to destroy themself through apoptosis.

The laureates discovered two new mechanisms that are used if some of the bad cells are left. Re-editing, where the immune system alters the combination of receptors, and anergy, that silences B cells with self-reactive receptors.

The laureates were able to demonstrate that these mechanisms sometimes fail. This means that faulty B cells can cause an attack on the body's own tissues – leading to autoimmune diseases.

Thanks to the laureate’s discoveries, doctors like Anders Bengtsson soon felt able to start treating patients with lupus, arthritis, multiple sclerosis, and many other autoimmune diseases, with medicines that eradicated B cells.

Anders Bengtsson: "I'm very happy that B cells has gotten so much attention because of the laureates. I have seen my patients getting so much better and getting a better life."

Autoimmune patient: "Today, I feel very good. I really have hope in the research that it will revolutionise things and perhaps even cure it all. That’s what I want, hope for, and believe in.""

-Article via Good News Network, April 6, 2025. Video via The Royal Swedish Academy of Sciences, January 29, 2025.

Please call this recession the Trump Slump.

We need to put Trump's name on this.

if ever anything I wrote were to ever go viral, let it be this. Let everyone talk about the Trump Slump. I want to hear this term in the news.

lets settle this properly

I have a theory

#A burger is the patty #veggie and turkey burgers have the patty consistency #a fried chicken breast is not a patty #therefore it's not a burger #you can have a chicken burger #but the chicken must be in ground patty form #This has been An American's Guide To Burgers (via @heartbranches)

Updated version of Boy Who Cried Wolf but there are actual wolves every single time and no one ever believes the boy - they get closer and closer every time he tries to warn them, until it's too late and the whole town screams at the boy for not warning them "enough", and blame him for the wolves at their door.

I want a story about a king whose son is prophesied to kill him so the king is like “whatever what am I supposed to do, kill my own kid wtf is wrong with you” so he just raises him as normal, doesn’t even tell him about the prophecy, and instead of some convoluted twist of events that leads to the king’s murder the son grows up and when the king is very old and dying and in excruciating pain the kid is just like alright I'mma put him out of his misery.

The king’s son becomes the new king, and is prophesied to defeat evil and bring an age of prosperity. His generals and knights all crack their knuckles but he pretty much ignores them and focuses on strengthening the infrastructure of his kingdom. Forty years later he is old and sick but still hearing his subjects’ grievances, and a general’s like “how will you defeat the prophesied evil now? You’re old and weak.” Another visitor, a teenager fresh out of the kingdom’s public education system, looks at the general like he is an ignoramus. The king eradicated poverty, housed the homeless, taught the ignorant, ended class exploitation by abolishing the nobility and imprisoning the corrupt, and established a highly respected guild of doctors that recently figured out how to cure the plague. There are no brigands because there is enough wealth for everyone to live comfortably; hiding in the woods and taking trinkets from people simply doesn’t make any sense for anyone but the desperate, and the people are not desperate. Evil is a weed, explains the teenager. It grows in cracked roads and crumbling houses and forgotten corners, rooted in indifference and watered by suffering. But the king demands that broken things be mended and suffering people be made well.

No evil lives in this kingdom, says the teenager. It starved to death before I was born.

Every once in a while, when I’m feeling down, I go and look at the notes on this post and they make me feel a lot better. This is the energy I want to carry into 2018.

For those who need to carry it into 2019.

And on to 2022

And into 2025

would you?

its just embarrassing when you make a fandom related post and it doesnt get any notes like okay. so no one want to play tuoys with me. no one wants to play with our little guys together. okay thats fine. yeah its cool... puts my hands in my jacket pockets. kicks a beer can that was on the side of the road a little

Sometimes I’m looking for something online - often “how to” articles - and I want to filter for - like - a website that was clearly built in 2010 at the latest, which may or may not have been updated since then, but contains a vast wealth of information on one topic, painstakingly organized by an unknown legend in the field with decades’ worth of experience. I don’t want a listicle with a nice stolen picture in a slideshow format written by a content aggregator that God forgot. I want hand-drawn diagrams by some genius professor who doesn’t understand SEO at all, but understands making stir-fries or raising stick insects better than anyone else on this earth. I don’t know what search settings to put into Google to get this.

thank you for articulating this cri de coeur for me

ngl these days i’m just happy when it’s not a video

search.marginalia.nu is the search engine you want!

“It is a search engine, designed to help you find what you didn’t even know you were looking for. If you search for “Plato”, you might for example end up at the Canterbury Tales. Go looking for the Canterbury Tales, and you may stumble upon Neil Gaiman’s blog.

If you are looking for fact, this is almost certainly the wrong tool. If you are looking for serendipity, you’re on the right track. When was the last time you just stumbled onto something interesting, by the way?

I don’t expect this will be the next “big” search engine. This is and will remain a niche tool for a niche audience.“

i clicked around for a few minutes searching various things and I now have two fourteenth century pie crust recipes and an apple filling recipe i want to try, so thanks!

it has been twenty minutes and I am deeply in love with this search engine.

INCREDIBLE. I *do* want to know how to test Windows 95 for Y2K Compliance and I am glad that someone is still hosting step by step instructions for that.

tl;dr: search.marginalia.nu for the old or old looking and just plain serendipitous stuff that google or Duck duck go are gonna not find/bury on the 20th page. For perfectly good reasons, but …

My absolute favorite part of having made this post - other than causing people to be introduced to this site - are the people in the tags/comments talking about their interests and stuff they found about their hobbies.

Good luck out there surfing the cyberweb, you crazy cats. I love the shoelace website too - Ian’s Shoelace Site [link], unless there’s another. My personal favorite old-school site is Alysion’s string figure collection [link].

HEY, FELLOW HATERS OF INSANELY-BRIGHT CAR HEADLIGHTS, SOMEONE HAS STARTED A PETITION TO REGULATE THEM.

It's an official petition through the Australian Government's e-petition page, which means if it gets enough signatures, it will be tabled in government.

You do have to be an Australian citizen to sign it, BUT!!! PLEASE REBLOG THIS EVEN IF YOURE NOT, because these kind of things have a roll-on effect, and if Australia legislates LED headlights, then other countries may follow.

FYI, the petition asks only for your name and email, and once you've clicked the sign button, they'll send you an email to confirm your signature --- you need to click the confirmation link in the email to have your signature counted.

it really is crazy how quickly people were willing to just let chatgpt do everything for them. i have never even tried it. brother i don't even know if it's just a website you go to or what. i do not know where chatgpt actually lives, because i can decide my own grocery list.