AB-PINACA

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AB-PINACA
AB-PINACA structure-rev1.png
Systematic (IUPAC) name
N-[(1S)-1-(aminocarbonyl)-2-methylpropyl]-1-pentyl-1H-indazole-3-carboxamide
Clinical data
Legal status
Identifiers
CAS Number 1445752-09-9 YesY
PubChem CID: 71301472
ChemSpider 28537615
Chemical data
Formula C18H26N4O2
Molecular mass 330.43 g/mol
  • CCCCCn1c2ccccc2c(n1)C(=O)N[C@@H](C(C)C)C(=O)N
  • InChI=1S/C18H26N4O2/c1-4-5-8-11-22-14-10-7-6-9-13(14)16(21-22)18(24)20-15(12(2)3)17(19)23/h6-7,9-10,12,15H,4-5,8,11H2,1-3H3,(H2,19,23)(H,20,24)/t15-/m0/s1
  • Key:GIMHPAQOAAZSHS-HNNXBMFYSA-N

AB-PINACA is a compound that was first identified as a component of synthetic cannabis products in Japan in 2012.[1]

It was originally developed by Pfizer in 2009 as an analgesic medication.[2][3]

AB-PINACA acts as a potent agonist for the CB1 receptor (Ki = 2.87 nM, EC50 = 1.2 nM) and CB2 receptor (Ki = 0.88 nM, EC50 = 2.5 nM) and fully substitutes for Δ9-THC in rat discrimination studies, while being 1.5x more potent.[4][5]

Side effects

There have been a number of reported cases of deaths and hospitalizations in relation to this synthetic cannabinoid.[6]

Legality

AB-PINACA is an Anlage II controlled substance in Germany as of November 2014.[7]

AB-PINACA is listed in the Fifth Schedule of the Misuse of Drugs Act (MDA) and therefore illegal in Singapore as of May 2015.[8]

It's a Schedule I controlled substance in the USA.[9]

As of October 2015 AB-PINACA is a controlled substance in China.[10]

See also

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References

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