NESS-040C5

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NESS-040C5
NESS-040C5 structure.png
Systematic (IUPAC) name
N-(2-isopropyl-5-methylcyclohexyl)-1-(4-methylbenzyl)-1,4-dihydrothieno[3',2':4,5]cyclopenta[1,2-c]pyrazole-3-carboxamide
Clinical data
Legal status
Identifiers
CAS Number 1445751-90-5
ATC code none
Chemical data
Formula C27H33N3OS
Molecular mass 447.64 g/mol
  • CC(C=C1)=CC=C1CN2C3=C(CC4=C3SC=C4)C(C(NC5CC(C)CCC5C(C)C)=O)=N2

NESS-040C5 is a potent cannabinoid agonist which was developed for the treatment of glaucoma.[1] It has reasonable selectivity for the CB2 receptor subtype, having a CB2 affinity of 0.4nM, and 25x selectivity over the related CB1 receptor.[2]

See also

References

  1. Paolo Lazzari et al. Pharmaceutical Compounds. US Patent 8106218
  2. Hanus LO, Mechoulam R. Novel natural and synthetic ligands of the endocannabinoid system. Current Medicinal Chemistry. 2010;17(14):1341-59. PMID 20166928

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