JWH-249

JWH-249

Systematic (IUPAC) name
2-(2-bromophenyl)-1-(1-pentylindol-3-yl)ethanone
Clinical data
Legal status	CA: Schedule II
Identifiers
CAS Number	864445-60-3 N
PubChem	CID: 44397335
ChemSpider	23253217 Y
ChEMBL	CHEMBL363471 Y
Chemical data
Formula	C21H22BrNO
Molecular mass	384.31 g/mol
SMILES CCCCCn1cc(c2c1cccc2)C(=O)Cc3ccccc3Br
InChI InChI=1S/C21H22BrNO/c1-2-3-8-13-23-15-18(17-10-5-7-12-20(17)23)21(24)14-16-9-4-6-11-19(16)22/h4-7,9-12,15H,2-3,8,13-14H2,1H3 Y Key:CGQRVOHECAULLB-UHFFFAOYSA-N Y
NY (what is this?)  (verify)

JWH-249 (1-pentyl-3-(2-bromophenylacetyl)indole) is a synthetic cannabinoid from the phenylacetylindole family, which acts as a cannabinoid agonist with about 2.4x selectivity for CB₁ with a K_i of 8.4nM ± 1.8 and 20nM ± 2 at CB₂. Similar to the related 2'-methoxy compound JWH-250, the 2'-chloro compound JWH-203, and the 2'-methyl compound JWH-251, JWH-249 has a phenylacetyl group in place of the naphthoyl ring used in most aminoalkylindole cannabinoid compounds.

See also

• AM-679