JWH-007

JWH-007

File:JWH-007 structure.png
Systematic (IUPAC) name
1-pentyl-2-methyl-3-(1-naphthoyl)indole
Clinical data
Legal status	DE: Anlage II (Prohibited)
Identifiers
CAS Number	155471-10-6 Y
PubChem	CID: 10360860
ChemSpider	8536309
Chemical data
Formula	C25H25NO
Molecular mass	355.471 g/mol
SMILES c14ccccc4cccc1C(=O)c3c2ccccc2n(c3C)CCCCC
InChI InChI=1S/C25H25NO/c1-3-4-9-17-26-18(2)24(22-14-7-8-16-23(22)26)25(27)21-15-10-12-19-11-5-6-13-20(19)21/h5-8,10-16H,3-4,9,17H2,1-2H3 Key:IBBNKINXTRKICJ-UHFFFAOYSA-N
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JWH-007 is an analgesic chemical from the naphthoylindole family, which acts as a cannabinoid agonist at both the CB₁ and CB₂ receptors. It was the most active of the first group of N-alkyl naphoylindoles discovered by the team led by John W Huffman, several years after the family was initially described with the discovery of the N-morpholinylethyl compounds pravadoline (WIN 48,098), WIN 55,225 (JWH-200) and WIN 55,212-2 by the Sterling Winthrop group. Several other N-alkyl substituents were found to be active by Huffman's team including the n-butyl, n-hexyl, 2-heptyl and cyclohexylethyl groups, but it was subsequently determined that the 2-methyl group on the indole ring is not required for CB₁ binding, and tends to increase affinity for CB₂ instead. Consequently, the 2-desmethyl derivative of JWH-007, JWH-018 has slightly higher binding affinity for CB₁, with an optimum binding of 9.00nM at CB₁ and 2.94nM at CB₂, and JWH-007 displayed optimum binding of 9.50nM at CB₁ and 2.94nM at CB₂.

Law

JWH-007 was banned in Sweden on 1 October 2010 as a hazardous good harmful to health, after being identified as an ingredient in "herbal" synthetic cannabis products.

JWH-007 is illegal in Poland since 08.06.2010 on the basis of 'Ustawa z dnia 15 kwietnia 2011 r. o zmianie ustawy o przeciwdziałaniu narkomanii' published in Dz.U. 2011 nr 105 poz. 614

As of October 2015 JWH-007 is a controlled substance in China.

See also

• JWH-015
• JWH-018
• JWH-019
• JWH-073
• List of JWH cannabinoids