Estrogen-related receptor

estrogen-related receptor alpha
Identifiers
Symbol	ESRRA
Alt. symbols	ESRL1
Entrez	2101
HUGO	3471
OMIM	601998
RefSeq	NM_004451
UniProt	P11474
Other data
Locus	Chr. 11 q12

estrogen-related receptor beta
Identifiers
Symbol	ESRRB
Alt. symbols	ESRL2
Entrez	2103
HUGO	3473
OMIM	602167
RefSeq	NM_004452
UniProt	O95718
Other data
Locus	Chr. 14 q24.3

estrogen-related receptor gamma
Identifiers
Symbol	ESRRG
Entrez	2104
HUGO	3474
OMIM	602969
RefSeq	NM_206595
UniProt	P62508
Other data
Locus	Chr. 1 q41

The ERRs are orphan nuclear receptors, meaning the identity of their endogenous ligand has yet to be unambiguously determined. They are named because of sequence homology with estrogen receptors, but do not appear to bind estrogens or other tested steroid hormones.

There are three human estrogen related receptors:

• ERRα (ESRRA)
• ERRβ (ESRRB)
• ERRγ (ESRRG)

ERRs bind to estrogen response elements and modulate transcription but are not activated by estrogens. They also have their own response elements: ERREs. ERRs have been associated with energy homeostasis, diabetes and cancer.

External links

• ERRalpha estrogen-related receptor at the US National Library of Medicine Medical Subject Headings (MeSH)
• estrogen receptor-related receptor beta at the US National Library of Medicine Medical Subject Headings (MeSH)
• ESRRB protein, human at the US National Library of Medicine Medical Subject Headings (MeSH)
• ESRRG protein, human at the US National Library of Medicine Medical Subject Headings (MeSH)