Poison "Manna di San Nicola" (Aqua Tofana), by Pierre Méjanel. Aqua Tofana (also known as Acqua Toffana and Aqua Tufania and Manna di San Nicola) was a strong poison created in Sicily around 1630[1] that was reputedly widely used in Palermo, Naples,[2] Perugia, and Rome, Italy. It has been associated with Giulia Tofana, or Tofania, a woman from Palermo, purportedly the leader of a ring of six pois