NESS-040C5

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NESS-040C5
NESS-040C5 structure.png
Systematic (IUPAC) name
N-(2-isopropyl-5-methylcyclohexyl)-1-(4-methylbenzyl)-1,4-dihydrothieno[3',2':4,5]cyclopenta[1,2-c]pyrazole-3-carboxamide
Clinical data
Legal status
Identifiers
CAS Number 1445751-90-5
ATC code none
Chemical data
Formula C27H33N3OS
Molecular mass 447.64 g/mol
  • CC(C=C1)=CC=C1CN2C3=C(CC4=C3SC=C4)C(C(NC5CC(C)CCC5C(C)C)=O)=N2

NESS-040C5 is a potent cannabinoid agonist which was developed for the treatment of glaucoma.[1] It has reasonable selectivity for the CB2 receptor subtype, having a CB2 affinity of 0.4nM, and 25x selectivity over the related CB1 receptor.[2]

See also

References

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  1. Paolo Lazzari et al. Pharmaceutical Compounds. US Patent 8106218
  2. Hanus LO, Mechoulam R. Novel natural and synthetic ligands of the endocannabinoid system. Current Medicinal Chemistry. 2010;17(14):1341-59. PMID 20166928