ING4
Lua error in Module:Infobox_gene at line 33: attempt to index field 'wikibase' (a nil value). Inhibitor of growth protein 4 is a protein that in humans is encoded by the ING4 gene.[1][2]
The protein encoded by this gene is similar to ING1, a tumor suppressor protein that can interact with TP53, inhibit cell growth, and induce apoptosis. This protein contains a PHD-finger, which is a common motif in proteins involved in chromatin remodeling. This protein can bind TP53 and EP300/p300, a component of the histone acetyl transferase complex, suggesting its involvement in the TP53-dependent regulatory pathway. Alternatively spliced transcript variants have been observed, but the biological validity of them has not been determined.[2]
Interactions
ING4 has been shown to interact with EP300,[1] RELA[3] and P53.[1][4]
References
Further reading
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External links
- ING4 protein, human at the US National Library of Medicine Medical Subject Headings (MeSH)
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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