TAL2

T-cell acute lymphocytic leukemia 2
Identifiers
Symbol	TAL2
External IDs	OMIM: 186855 MGI: 99540 HomoloGene: 3954 GeneCards: TAL2 Gene
Gene ontology Molecular function • RNA polymerase II regulatory region sequence-specific DNA binding • RNA polymerase II transcription factor activity, sequence-specific DNA binding • DNA binding • protein binding • protein dimerization activity Cellular component • nucleus Biological process • transcription, DNA-templated • regulation of transcription from RNA polymerase II promoter • post-embryonic development • thalamus development • midbrain development • multicellular organism growth Sources: Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	6887	21350
Ensembl	ENSG00000186051	ENSMUSG00000028417
UniProt	Q16559	Q62282
RefSeq (mRNA)	NM_005421	NM_009317
RefSeq (protein)	NP_005412	NP_033343
Location (UCSC)	Chr 9: 105.66 – 105.66 Mb	Chr 4: 53.78 – 53.79 Mb
PubMed search	[1]	[2]

T-cell acute lymphocytic leukemia 2, also known as TAL2, is a protein which in humans is encoded by the TAL2 gene.

Function

TAL2 is a member of the basic helix-loop-helix family of transcription factors.

Clinical significance

Tumor-specific alterations of the TAL2 gene occurs in some patients with T-cell acute lymphoblastic leukemia (T-ALL).