RAR-related orphan receptor beta

RAR-related orphan receptor B
PDB rendering based on 1k4w.
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 1k4w, 1n4h, 1nq7
Identifiers
Symbols	RORB ; NR1F2; ROR-BETA; RZR-BETA; RZRB; bA133M9.1
External IDs	OMIM: 601972 MGI: 1343464 HomoloGene: 38250 IUPHAR: 599 GeneCards: RORB Gene
Gene ontology Molecular function • transcription factor activity, sequence-specific DNA binding • steroid hormone receptor activity • RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding • protein binding • transcription factor binding • zinc ion binding • melatonin receptor activity • sequence-specific DNA binding Cellular component • nucleus • nucleoplasm Biological process • regulation of transcription, DNA-templated • transcription initiation from RNA polymerase II promoter • G-protein coupled receptor signaling pathway • brain development • visual perception • circadian rhythm • gene expression • intracellular receptor signaling pathway • amacrine cell differentiation • eye photoreceptor cell development • regulation of circadian rhythm • steroid hormone mediated signaling pathway • negative regulation of osteoblast differentiation • negative regulation of transcription, DNA-templated • positive regulation of transcription, DNA-templated • retinal rod cell development • retinal cone cell development • retina development in camera-type eye • cellular response to retinoic acid Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	6096	225998
Ensembl	ENSG00000198963	ENSMUSG00000036192
UniProt	Q92753	Q8R1B8
RefSeq (mRNA)	NM_006914	NM_001043354
RefSeq (protein)	NP_008845	NP_001036819
Location (UCSC)	Chr 9: 74.5 – 74.69 Mb	Chr 19: 18.93 – 19.11 Mb
PubMed search	[1]	[2]

RAR-related orphan receptor beta (ROR-beta), also known as NR1F2 (nuclear receptor subfamily 1, group F, member 2) is a nuclear receptor that in humans is encoded by the RORB gene.

Function

The protein encoded by this gene is a member of the NR1 subfamily of nuclear hormone receptors. It is a DNA-binding protein that can bind as a monomer or as a homodimer to hormone response elements upstream of several genes to enhance the expression of those genes. The specific functions of this protein are not known, but it has been shown to interact with NM23-2, a nucleoside-diphosphate kinase involved in organogenesis and differentiation.

In the brain, ROR-beta is concentrated in layer 4 of the cerebral cortex, where it plays a role in the development of structures such as barrel columns.

Interactions

RAR-related orphan receptor beta has been shown to interact with NME1.

See also

• RAR-related orphan receptor

External links

• orphan nuclear receptor ROR-beta at the US National Library of Medicine Medical Subject Headings (MeSH)