NKX3-2

NK3 homeobox 2
Identifiers
Symbols	NKX3-2 ; BAPX1; NKX3.2; NKX3B; SMMD
External IDs	OMIM: 602183 HomoloGene: 68168 GeneCards: NKX3-2 Gene
Gene ontology Molecular function • RNA polymerase II core promoter proximal region sequence-specific DNA binding • transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding Cellular component • nucleus Biological process • negative regulation of transcription from RNA polymerase II promoter • skeletal system development • transcription from RNA polymerase II promoter • determination of left/right symmetry • pancreas development • negative regulation of chondrocyte differentiation • middle ear morphogenesis • negative regulation of apoptotic process • spleen development • organ formation • skeletal system morphogenesis • embryonic skeletal system development • intestinal epithelial cell development Sources: Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	579	12020
Ensembl	ENSG00000109705	ENSMUSG00000049691
UniProt	P78367	P97503
RefSeq (mRNA)	NM_001189	NM_007524
RefSeq (protein)	NP_001180	NP_031550
Location (UCSC)	Chr 4: 13.54 – 13.55 Mb	Chr 5: 41.76 – 41.76 Mb
PubMed search	[1]	[2]

NK3 homeobox 2 also known as NKX3-2 is a human gene. It is a homolog of bagpipe(bap) in Drosophila and therefore also known as Bapx1 (bagpipe homeobox homolog 1) . The protein encoded by this gene is a homeo domain containing transcription factor.

Function

NKX3-2 plays a role in the development of the skeleton. Nkx3-2 in mice also regulates patterning in the middle ear.

External links

• Bapx1 protein, mouse at the US National Library of Medicine Medical Subject Headings (MeSH)