NPAS2

Neuronal PAS domain protein 2
Identifiers
Symbols	NPAS2 ; MOP4; PASD4; bHLHe9
External IDs	OMIM: 603347 MGI: 109232 HomoloGene: 1887 GeneCards: NPAS2 Gene
Gene ontology Molecular function • core promoter binding • DNA binding • transcription factor activity, sequence-specific DNA binding • protein binding • metal ion binding • protein dimerization activity • Hsp90 protein binding Cellular component • nucleus • nucleoplasm • transcription factor complex • cytosol Biological process • transcription, DNA-templated • cellular response to DNA damage stimulus • central nervous system development • circadian rhythm • circadian regulation of gene expression • circadian sleep/wake cycle • cellular lipid metabolic process • small molecule metabolic process • locomotor rhythm • positive regulation of DNA repair • positive regulation of transcription, DNA-templated • positive regulation of transcription from RNA polymerase II promoter • response to redox state • negative regulation of cell death • regulation of response to DNA damage stimulus Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	4862	18143
Ensembl	ENSG00000170485	ENSMUSG00000026077
UniProt	Q99743	P97460
RefSeq (mRNA)	NM_002518	NM_008719
RefSeq (protein)	NP_002509	NP_032745
Location (UCSC)	Chr 2: 100.82 – 101 Mb	Chr 1: 39.19 – 39.36 Mb
PubMed search	[1]	[2]

Neuronal PAS domain-containing protein 2 is a protein that in humans is encoded by the NPAS2 gene.

Function

The protein encoded by this gene is a member of the basic helix-loop-helix (bHLH)-PAS family of transcription factors. A similar mouse protein may play a regulatory role in the acquisition of specific types of memory. It also may function as a part of a molecular clock operative in the mammalian forebrain.

NPAS2 has been shown to be analogous to the function of CLOCK in CLOCK deficient mice.

Interactions

NPAS2 has been shown to interact with:

• ARNTL,
• EP300, and
• Retinoic acid receptor alpha.

External links

• NPAS2 protein, human at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.