NPAS2

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Neuronal PAS domain protein 2
Identifiers
Symbols NPAS2 ; MOP4; PASD4; bHLHe9
External IDs OMIM603347 MGI109232 HomoloGene1887 GeneCards: NPAS2 Gene
RNA expression pattern
PBB GE NPAS2 39548 at tn.png
PBB GE NPAS2 205459 s at tn.png
PBB GE NPAS2 205460 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 4862 18143
Ensembl ENSG00000170485 ENSMUSG00000026077
UniProt Q99743 P97460
RefSeq (mRNA) NM_002518 NM_008719
RefSeq (protein) NP_002509 NP_032745
Location (UCSC) Chr 2:
100.82 – 101 Mb
Chr 1:
39.19 – 39.36 Mb
PubMed search [1] [2]

Neuronal PAS domain-containing protein 2 is a protein that in humans is encoded by the NPAS2 gene.[1][2]

Function

The protein encoded by this gene is a member of the basic helix-loop-helix (bHLH)-PAS family of transcription factors. A similar mouse protein may play a regulatory role in the acquisition of specific types of memory. It also may function as a part of a molecular clock operative in the mammalian forebrain.[3]

NPAS2 has been shown to be analogous to the function of CLOCK in CLOCK deficient mice.[4]

Interactions

NPAS2 has been shown to interact with:

References

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External links

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This article incorporates text from the United States National Library of Medicine, which is in the public domain.