The document describes the processes involved in the production of aspirin and caffeine extraction, as well as packaging. Key steps in aspirin production include acetylation using a batch reactor at 88-92°C, filtration using a rotary vacuum drum filter at 90°C, crystallization using an agitated batch crystallizer cooled to 10-25°C, centrifugation at 25°C, drying using a rotary drum dryer at 60-70°C, and extractive distillation using a distillation column. Caffeine extraction steps are also outlined. Final packaging involves mixing, sieving, size reduction using a hammer mill, and compression into tablets using a rotary tablet machine, all at room temperature.
The document describes the processes involved in the production of aspirin and caffeine extraction, as well as packaging. Key steps in aspirin production include acetylation using a batch reactor at 88-92°C, filtration using a rotary vacuum drum filter at 90°C, crystallization using an agitated batch crystallizer cooled to 10-25°C, centrifugation at 25°C, drying using a rotary drum dryer at 60-70°C, and extractive distillation using a distillation column. Caffeine extraction steps are also outlined. Final packaging involves mixing, sieving, size reduction using a hammer mill, and compression into tablets using a rotary tablet machine, all at room temperature.
The document describes the processes involved in the production of aspirin and caffeine extraction, as well as packaging. Key steps in aspirin production include acetylation using a batch reactor at 88-92°C, filtration using a rotary vacuum drum filter at 90°C, crystallization using an agitated batch crystallizer cooled to 10-25°C, centrifugation at 25°C, drying using a rotary drum dryer at 60-70°C, and extractive distillation using a distillation column. Caffeine extraction steps are also outlined. Final packaging involves mixing, sieving, size reduction using a hammer mill, and compression into tablets using a rotary tablet machine, all at room temperature.
The document describes the processes involved in the production of aspirin and caffeine extraction, as well as packaging. Key steps in aspirin production include acetylation using a batch reactor at 88-92°C, filtration using a rotary vacuum drum filter at 90°C, crystallization using an agitated batch crystallizer cooled to 10-25°C, centrifugation at 25°C, drying using a rotary drum dryer at 60-70°C, and extractive distillation using a distillation column. Caffeine extraction steps are also outlined. Final packaging involves mixing, sieving, size reduction using a hammer mill, and compression into tablets using a rotary tablet machine, all at room temperature.
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I.
Aspirin Production
Process Equipment Operating Operating Other Details
Pressure Temperature Acetylation Agitated 1 atm 88-92˚C Reaction Time: 2-3 hrs Batch Reactor Heating Rate Constant: 0.3 l/mol-hr Medium: (To be Superheated 95% Conversion of Salicylic acid designed) steam or hot water 20% stoichiometric excess of acetic anhydride and 10% by wt concentrated sulfuric acid (based on the mass of salicylic acid) Optimum Reaction Sources: Temperature: https://www.chegg.com/homework-help/questions-and-answers/manufacture- 90˚C aspirin-acetylsalicylic-acid-synthesized-using-reaction-salicylic-acid-acetic--q5050378 Chemical Reactions and Chemical Reactors by George W. Roberts Encyclopedia of Chemical Processing and Design- Volume 4 by John McKetta Jr. http://eleceng.dit.ie/gavin/DT275/Module%201/Assignment.htm?fbclid=IwAR371JVkl Raifzm6CrBiQplSw6SNVqmL3pxewgYE41J59foI72GhYUnevOo Filtration Rotary 1 atm 90˚C Vacuum Sources: Drum Filter Chemical Reactions and Chemical Reactors by George W. Roberts Crystallization Agitated 1 atm Cooling The cooling water from the cooling tower is used to precipitate aspirin at low temperature. Batch water: 10- Crystallizer 25˚C Aspirin Mixture Temperature: 10˚C Sources: (To be Encyclopedia of Chemical Processing and Design- Volume 4 by John McKetta Jr. designed) Centrifugation Centrifugal 1 atm 25˚C The mother liquor contains 10-20% aspirin. Bowl/ Continuous Sources: Centrifuge Encyclopedia of Chemical Processing and Design- Volume 4 by John McKetta Jr. Drying Rotary 1 atm 60-70 ˚C Initial moisture content: 22% wet basis Drum Final moisture content: 0.1% wet basis Dryer Source (To be Perry’s Chemical Engineering Handbook 8th Edition designed) Encyclopedia of Chemical Processing and Design- Volume 4 by John McKetta Jr. Extractive Distillation 1 atm Feed: 29 wt% Acetic Acid (Subcooled Liquid) Distillation Column Distillate: 99.5 wt% Water (Saturated Liquid) Bottoms: 99% Acetic Acid (Saturated Liquid) (To be Reflux Ratio: 4.76 designed) Use Ponchon-Savarit Method (Acetic Acid-Water System) to determine the number of plates and the duties of condenser and reboiler.
Cooling Cooling 1 atm Process water is cooled which will be used to precipitate aspirin in the crystallizer Tower Source: Perry’s Chemical Engineering Handbook 8th Edition
II. Caffeine Extraction
Process Equipment Operating Operating Other Details
Pressure Temperature III. Packaging
Process Equipment Operating Operating Other Details
