Anonymous asked:
Post-viral fatigue: When was it first officially recognized as A Thing? Was it unofficially observed much before then? What did the early documentation of it in medical literature/practice look like? How has our understanding of it evolved?
For this, since it is about history, I’m going to be talking mostly about our understanding of post-viral fatigue syndrome in a pre-covid context.
I have also decided to use sources describing what would later be termed ME/CFS. While viruses are only one trigger for ME/CFS, early reports tended to notice that ME/CFS clustered in outbreaks, which speaks to a viral, bacterial, or parasite trigger (for example, an outbreak of a viral illness happens, then just afterwards, an ME/CFS or post-viral syndrome outbreak does).
Finally, it is important to note that viruses are not the only infectious agent that can cause a fatigue syndrome. Bacteria (particularly strep) and even parasites (most notably giardia and malaria) have been known to cause it. As this is a history post, it generally will not be possible to differentiate the cause of any given outbreak, so I’m kind of lumping them in together.
————————
Let’s begin:
Between 1860 and 1880, a new disease arrived on the scene. It was called neurasthenia, and it was described:
Neurasthenia is a condition of nervous exhaustion,
characterised by undue fatigue on slightest exertion, both physical and mental, with which are associated symptoms of abnormal functioning, mainly referable to disorders of the vegetative nervous system. The chief symptoms are headache, gastrointestinal disturbances, and subjective sensations of all kinds.
It probably wasn’t actually new, but instead first recognized here due to the recent industrial revolution and change in work patterns. It was considered to strike upper-class men (as a consequence of their hard mental work) specifically, and thought not to strike the lower classes, women, or racial minorities (who surely never engaged in such work).
Between 1880 and 1900, in the UK, explanation after explanation was posited as the reason for the illness. It was due to overwork, or underwork. Due to a lack of electrical energy. Due to a physical insult like an infection or metabolic disturbance. Due to the law of thermodynamics playing out in the body. Basically, if the scientific community found a new cool theory, it was applied to explain neurasthenia. None of these, however, were able to be definitively proven with the technology of the time.
One thing, however, was consistent- the treatment. Like a number of other illnesses, it was sending someone to a retreat, rest home, or other place where they could experience physical and mental rest. This is also the first time “chronic fatigue” was used in the literature. Based on what we know today, this was probably a good option.
By the early 20th century, unable to find an explanation that stuck, however, physicians threw their hands up. It was all just a weird form of melancholia, they said. It is important to note here that psychiatry and neurology would not become distinct fields until after WWII. So it was mostly neurologists saying “hey, we can’t figure out what causes this, so we’re going to lump it in with another thing we can’t figure out the cause of that also makes people stay in bed all the time.”
This was followed very swiftly by other physicians, several of whom had neurasthenia themselves, advocating for it to continue to be considered it’s own separate neurological condition. Unfortunately, the melancholia label stuck, and the view of it as an upper class disease that only affected men quickly flipped to one that was only experienced by the lower classes and women.
Whether understood as physical, mental, or a combination, however, the early 1900s brought with it another explanation for the problem- febrile illness. It was noted that chronic fatigue syndromes frequently followed malaria, flu, and other illnesses that caused fever. This was not the first time this had been postulated, but it was the first time it attained widespread acceptance. The lack of persistence of the culprit (at the time bacteria or parasite), however, only lent more credibility to the idea that it was mental in nature, and it was largely forgotten about.
In 1934, a series of outbreaks of what was thought to be an abnormal form of polio struck around the world. Once it was differentiated, it would be named epidemic neuromyasthenia. This was seen as a brand new illness, not connected to neurasthenia.
By the 1950s, the term had changed to “benign myalgic encephalomyelitis”, which was chosen due to
the absent mortality, the severe muscular pains, the evidence of parenchymal damage to the nervous system, and the presumed inflammatory nature of the disorder,
as described in a 1959 paper on the subject. It was recognized that the disease came in both epidemic and sporadic cases, but the scientific community wasn’t entirely sure what caused it. Still, the number of papers about it suggested they were looking (unfortunately, most of these papers are not available, even in abstract form).
The next problem happened in 1970. Two psychiatrists named McEvedy and Beard wrote a paper that analyzed an outbreak that occurred in 1955, proclaimed it a case of mass hysteria without talking to any of the patients, and retroactively concluded that all previous outbreaks dating back to 1934 had also been mass hysteria. Over the next 8 years, there were many papers vehemently refuting this claim, by at least 5 different authors that I could find.
Unfortunately, instead of the rebuttals cementing McEvedy and Beard as not knowing what they were talking about, it created a deep rift in the scientific community: did the disease belong to psychiatrists, neurologists, both, or someone else entirely?
People working on the physical end in the 1980s pointed to high rates of viral titers for specific viruses, circulating immune complexes, muscle biopsies showing necrosis, abnormal jitter potentials, and abnormally early acid production during exercise, among other things. Basically, there’s something wrong with how the immune system is working, and also something very wrong with the physiology of the muscles.
People working on the mental end pointed to mass hysteria and high rates of anxiety, depression, and emotional liability in people with myalgic encephalomyelitis, combined with a then relatively new understanding that mental illness sometimes does wonky things with the immune system.
Note that, for the mental end of things, some of the sources cited in these papers are exceptionally old for scientific papers, like, going back to neurasthenia days and the original 1900s explanations of neurasthenia as melancholia.
Because the two camps couldn’t get along (I have no proof, but I know neurology and psychiatry fought like cats and dogs for long swaths of the 20th century, so it honestly might have been a professional scrap that made this illness so fraught), “post-viral syndrome”, and later “post-infectious fatigue syndrome” were coined because they didn’t specifically point to physical or mental being the primary reason for the syndrome.
And this argument continued into the 2020s, and in some cases until today. The COVID-19 pandemic did finally settle it largely into a physical illness with some psychological features (rather than a psychological illness with some physical features). But it can still be exceptionally difficult to get diagnosed and correctly treated depending on where a person is and what doctor they have.
In conclusion, the history of post-infectious fatigue syndrome has gone through many names and many phases, and there was a lot to the story I wish I could have covered in this post, but it was already really long. Hopefully this gives you some understanding of the social and scientific history of this syndrome.